INT21686

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Context Info
Confidence 0.42
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 13.79
Pain Relevance 4.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
AtT-20 8
retina 4
cardiovascular system 4
liver 2
hepatocytes 2
ras (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 1 99.68 Very High Very High Very High
tetrodotoxin 41 99.20 Very High Very High Very High
cytokine 19 98.96 Very High Very High Very High
Inflammation 45 98.76 Very High Very High Very High
sodium channel 4 93.36 High High
addiction 5 90.44 High High
metalloproteinase 7 86.48 High High
Inflammatory response 4 78.12 Quite High
cINOD 14 67.24 Quite High
aspirin 1 65.40 Quite High
Disease Link Frequency Relevance Heat
Infection 142 99.98 Very High Very High Very High
Hypertrophy 20 99.90 Very High Very High Very High
Cytomegalovirus Infection 192 99.78 Very High Very High Very High
INFLAMMATION 56 99.68 Very High Very High Very High
Hypoxia 57 99.52 Very High Very High Very High
Cancer 276 99.12 Very High Very High Very High
Diabetes Mellitus 92 98.84 Very High Very High Very High
Hypertension 130 98.76 Very High Very High Very High
Hepatocellular Cancer 64 98.16 Very High Very High Very High
Watson Syndrome 38 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transfection of activated ras into an excitable cell line (AtT-20) alters tetrodotoxin sensitivity of voltage-dependent sodium current.
Positive_regulation (Transfection) of Gene_expression (Transfection) of ras in AtT-20 associated with tetrodotoxin
1) Confidence 0.42 Published 1990 Journal Pflugers Arch. Section Title Doc Link 2191273 Disease Relevance 0.09 Pain Relevance 0.90
The rate of inactivation of the TTX-resistant current in control cells was slower, than that of the TTX-sensitive current in either control or ras-transfected AtT-20 cells.
Positive_regulation (transfected) of Gene_expression (transfected) of ras in AtT-20 associated with tetrodotoxin
2) Confidence 0.42 Published 1990 Journal Pflugers Arch. Section Abstract Doc Link 2191273 Disease Relevance 0.08 Pain Relevance 0.93
Transfection of activated ras into an excitable cell line (AtT-20) alters tetrodotoxin sensitivity of voltage-dependent sodium current.
Positive_regulation (activated) of Gene_expression (Transfection) of ras in AtT-20 associated with tetrodotoxin
3) Confidence 0.42 Published 1990 Journal Pflugers Arch. Section Title Doc Link 2191273 Disease Relevance 0.09 Pain Relevance 0.90
The overexpression of MYC (as a transgene) and other oncogenes (e.g., RAS, T antigen) in murine hepatocytes results in HCC (Sandgren et al. 1989).
Positive_regulation (overexpression) of Gene_expression (overexpression) of RAS in hepatocytes associated with hepatocellular cancer
4) Confidence 0.40 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 1.16 Pain Relevance 0
AtT-20 cells transfected with the c-Ha-ras gene expressed only a TTX-sensitive current.
Positive_regulation (transfected) of Gene_expression (transfected) of ras in AtT-20 associated with tetrodotoxin
5) Confidence 0.37 Published 1990 Journal Pflugers Arch. Section Abstract Doc Link 2191273 Disease Relevance 0.10 Pain Relevance 0.97
Captopril altered the liver RAS
Positive_regulation (altered) of Gene_expression (altered) of RAS in liver
6) Confidence 0.29 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 0.65 Pain Relevance 0
Thus, the widespread activation of MEK1/2 and phosphorylation of p44 MAPK (ERK1) observed in HCCs could reflect constitutive activation mediated by absence of growth inhibitor [10] or over-expression of ras [44], IGF-II [10], TGF-?
Positive_regulation (over) of Gene_expression (over) of ras
7) Confidence 0.19 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.62 Pain Relevance 0
In addition, salicylate treated animals exerted significantly more force in response to the startle stimulus only when compared to controls both during pASR (Figure 4A) testing (0.90±0.08; p<0.0001 1 hr after injection; 0.93±0.14; p<0.0001 seven hrs after injection) and gASR (Figure 4B) testing (0.22±0.04; p?
Positive_regulation (response) of Gene_expression (testing) of pASR
8) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002264 Disease Relevance 0.23 Pain Relevance 0
In addition, salicylate treated animals exerted significantly more force in response to the startle stimulus only when compared to controls both during pASR (Figure 4A) testing (0.90±0.08; p<0.0001 1 hr after injection; 0.93±0.14; p<0.0001 seven hrs after injection) and gASR (Figure 4B) testing (0.22±0.04; p?
Positive_regulation (during) of Gene_expression (testing) of pASR
9) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002264 Disease Relevance 0.23 Pain Relevance 0
Additionally, we find that besides stimulating expression of inflammatory cytokines reported to increase blood pressure, CMV infection stimulated expression of renin, the first component of RAS, in both kidney cells and EC, in a dose-dependent manner (Fig. 4, Fig. 7).
Positive_regulation (stimulated) of Gene_expression (expression) of RAS in kidney associated with inflammation, cytomegalovirus infection, infection and cytokine
10) Confidence 0.17 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.15 Pain Relevance 0.14
The retinas from 4-week diabetic mice were subjected to immunoblot analyses to detect the production of the RAS components and its downstream ERK activation (Fig. 1).
Positive_regulation (activation) of Gene_expression (production) of RAS in retinas associated with diabetes mellitus
11) Confidence 0.11 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.67 Pain Relevance 0
Increased levels of RAS-GTP have previously been shown in MPNSTs from NF1 patients [29-31], caused perhaps by loss of the RAS-GAP-function of the NF1 gene product, neurofibromin.
Positive_regulation (Increased) of Gene_expression (levels) of RAS associated with watson syndrome
12) Confidence 0.07 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 1.32 Pain Relevance 0
To ascertain the effect of the Sulindac metabolites on the RAS signaling pathway, we determined the levels of RAS-GTP by affinity precipitation and western blotting with a monoclonal RAS antibody, as well as activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2).
Positive_regulation (activation) of Gene_expression (antibody) of RAS
13) Confidence 0.06 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 0.62 Pain Relevance 0
and components of the renin-angiotensin system (RAS) are expressed in the
Positive_regulation (components) of Gene_expression (expressed) of RAS
14) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 0.86 Pain Relevance 0.17
Ang II is the key effector of RAS and a vasoconstrictor acting in the cardiovascular system.23 Li et al.24 have shown that the gene expressions of all components of RAS were elevated in the heart and aorta of the SHR compared with Wistar Kyoto rats.
Positive_regulation (elevated) of Gene_expression (expressions) of RAS in cardiovascular system associated with hypertension
15) Confidence 0.05 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020347 Disease Relevance 1.07 Pain Relevance 0
These findings suggest that RAS expression is not constant, even in the various cell types of a single tissue such as retina.
Neg (not) Positive_regulation (constant) of Gene_expression (expression) of RAS in retina
16) Confidence 0.04 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2861126 Disease Relevance 0.14 Pain Relevance 0
COX-2 expression is induced both by the RAS/mitogen-activated protein kinase signalling pathway and by inflammatory stimuli, including carcinogens that increase tumour necrosis factor-induced nuclear factor-?
Positive_regulation (induced) of Gene_expression (pathway) of RAS associated with necrosis, cancer and inflammatory stimuli
17) Confidence 0.04 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064113 Disease Relevance 1.12 Pain Relevance 0.25
Ang II is the key effector of RAS and a vasoconstrictor acting in the cardiovascular system.23 Li et al.24 have shown that the gene expressions of all components of RAS were elevated in the heart and aorta of the SHR compared with Wistar Kyoto rats.
Positive_regulation (elevated) of Gene_expression (expressions) of RAS in cardiovascular system associated with hypertension
18) Confidence 0.04 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020347 Disease Relevance 1.15 Pain Relevance 0
Li et al.24 have suggested that the LVH in SHR was associated with ACE and ACE2 gene expression cardiac RAS, while aortic hypertrophy was associated with angiotensinogen and ACE2 gene expression of aortic RAS.
Positive_regulation (associated) of Gene_expression (expression) of RAS associated with hypertrophy, left ventricular hypertrophy and hypertension
19) Confidence 0.03 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020347 Disease Relevance 0.77 Pain Relevance 0
To determine whether VPA modulated the MAPK pathway upstream or downstream of Ras, the effects of VPA were investigated in L929 cells expressing constitutively active Ras (caRas).
Positive_regulation (active) of Gene_expression (expressing) of Ras in L929
20) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0

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