INT216869

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Context Info
Confidence 0.86
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.30
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HSD11B1) oxidoreductase activity (HSD11B1) endoplasmic reticulum (HSD11B1)
Anatomy Link Frequency
kidney 1
HSD11B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 31 97.28 Very High Very High Very High
Pain 15 72.96 Quite High
Potency 1 58.96 Quite High
alcohol 6 57.44 Quite High
Kinase C 1 21.28 Low Low
cytokine 5 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 79 100.00 Very High Very High Very High
INFLAMMATION 34 97.28 Very High Very High Very High
Hypertension 2 78.36 Quite High
Obesity 11 76.56 Quite High
Nicotine Addiction 8 73.04 Quite High
Pain 16 72.96 Quite High
Bronchitis 3 70.36 Quite High
Chronic Disease 13 70.08 Quite High
Stroke 4 68.80 Quite High
Myocardial Infarction 11 68.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Correlation between SRH (3 groups) and HDL-C (the dependents) and various independent factors
Protein_catabolism (groups) of HDL associated with disorder of lipid metabolism
1) Confidence 0.86 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC2096714 Disease Relevance 1.32 Pain Relevance 0.10
As shown by de Beer and colleagues, sPLA2-IIA dependent hydrolysis of HDL results in a more efficient scavenger receptor class B type I cholesteryl ester uptake, leading to an accelerated HDL catabolism in the kidney during inflammatory states (deBeer et al 2000).
Protein_catabolism (hydrolysis) of HDL in kidney associated with inflammation and disorder of lipid metabolism
2) Confidence 0.15 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.99 Pain Relevance 0.16

General Comments

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