INT21687

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Context Info
Confidence 0.58
First Reported 1980
Last Reported 2011
Negated 9
Speculated 2
Reported most in Abstract
Documents 143
Total Number 148
Disease Relevance 97.34
Pain Relevance 27.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 7
kidney 5
brain 3
carotid body 3
colon 3
ras (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 109 100.00 Very High Very High Very High
anesthesia 63 100.00 Very High Very High Very High
Myofascial pain syndrome 36 100.00 Very High Very High Very High
Chronic pancreatitis 17 100.00 Very High Very High Very High
nociceptor 9 100.00 Very High Very High Very High
qutenza 4 100.00 Very High Very High Very High
Migraine 40 99.80 Very High Very High Very High
dexamethasone 26 99.80 Very High Very High Very High
Enkephalin 4 99.68 Very High Very High Very High
ischemia 195 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 1494 100.00 Very High Very High Very High
Canker Sores 76 100.00 Very High Very High Very High
Myofascial Pain Syndromes 36 100.00 Very High Very High Very High
Pancreatitis 18 100.00 Very High Very High Very High
Infection 521 99.98 Very High Very High Very High
Diabetes Mellitus 630 99.96 Very High Very High Very High
Metabolic Syndrome 86 99.84 Very High Very High Very High
Increased Venous Pressure Under Development 239 99.80 Very High Very High Very High
Headache 61 99.80 Very High Very High Very High
Hyperplasia 49 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transfection of activated ras into an excitable cell line (AtT-20) alters tetrodotoxin sensitivity of voltage-dependent sodium current.
Positive_regulation (activated) of ras in AtT-20 associated with tetrodotoxin
1) Confidence 0.58 Published 1990 Journal Pflugers Arch. Section Title Doc Link 2191273 Disease Relevance 0.09 Pain Relevance 0.90
The functional role of Ras activation was studied by a single intraperitoneal injection of the neutral sphingomyelinase and farnesyltransferase inhibitor (FTI) manumycin A (1 mg/kg), which lowers induction of Ras-GTP and serum amounts of alanine aminotransferase (ALT).
Positive_regulation (induction) of Ras
2) Confidence 0.53 Published 2009 Journal Hepatology Section Abstract Doc Link 19739265 Disease Relevance 0.64 Pain Relevance 0.72
To better understand the contributions of different signaling pathways, the expression and role of Ras activation was evaluated after oral dosing of mice with APAP (400-500 mg/kg).
Positive_regulation (activation) of Ras associated with paracetamol
3) Confidence 0.53 Published 2009 Journal Hepatology Section Abstract Doc Link 19739265 Disease Relevance 0.44 Pain Relevance 0.58
Although atypical hyperplasia around cancer was histologically very similar to that found in chronic pancreatitis, all 5 atypical and 5 nonatypical hyperplasias in chronic pancreatitis were negative for ras point mutation.
Positive_regulation (negative) of ras associated with cancer, chronic pancreatitis and hyperplasia
4) Confidence 0.41 Published 1993 Journal Int. J. Pancreatol. Section Abstract Doc Link 8113625 Disease Relevance 1.80 Pain Relevance 0.50
Although the mechanism is not yet fully understood, investigators have noticed lower prevalence rate of RAS in smokers when compared to nonsmokers,4–8 increase in the incidence of RAS following smoking cessation,9–11 and resolution of lesions upon resumption of cigarette smoking.12,13 Although the highest incidence of RAS reported in the literature was found in young adults, particularly university students14,15 in whom the habit of smoking is prevalent, no studies were conducted on this group to verify this commonly held perception of smoking protection from RAS.
Positive_regulation (increase) of RAS associated with nicotine addiction and canker sores
5) Confidence 0.40 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2999509 Disease Relevance 2.11 Pain Relevance 0.07
During treatment in group 1, all thresholds increased progressively in TrPs and RAs (P < .0001), with sensory normalization of skin/subcutis in RAs at the end of treatment; migraine pain decreased (P < .001).
Positive_regulation (increased) of RAs in skin associated with pain, migraine and myofascial pain syndrome
6) Confidence 0.40 Published 2007 Journal J Pain Section Abstract Doc Link 17690015 Disease Relevance 1.94 Pain Relevance 1.87
Threshold increase in RAs and migraine reduction correlated linearly (.0001 < P < .006).
Positive_regulation (increase) of RAs associated with migraine
7) Confidence 0.40 Published 2007 Journal J Pain Section Abstract Doc Link 17690015 Disease Relevance 2.18 Pain Relevance 2.10
Another potential cause of reduced insulin sensitivity through RAS activation may be a result of vasoconstrictive effects, thereby reducing blood flow to skeletal muscle (Furuhashi et al 2003).
Positive_regulation (activation) of RAS in skeletal muscle
8) Confidence 0.39 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 1.05 Pain Relevance 0.03
Furthermore, activation of the RAS is significant in the pathogenesis of cardiovascular processes.
Positive_regulation (activation) of RAS
9) Confidence 0.39 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.53 Pain Relevance 0.04
Results from studies have confirmed that pantoprazole is superior to H(2)RAs in speed of healing and symptom relief in patients with peptic ulcer.
Positive_regulation (superior) of RAs in superior associated with ulcers
10) Confidence 0.37 Published 1999 Journal Drugs Today Section Abstract Doc Link 12973372 Disease Relevance 0.73 Pain Relevance 0.12
CONCLUSION: This study identifies a key role for Ras activation and demonstrates the therapeutic efficacy of FTIs during APAP-induced liver injury.
Positive_regulation (activation) of Ras in liver associated with paracetamol and injury
11) Confidence 0.35 Published 2009 Journal Hepatology Section Abstract Doc Link 19739265 Disease Relevance 0.64 Pain Relevance 0.76
Ras-guanosine triphosphate (GTP) is induced early and in an oxidative stress-dependent manner.
Positive_regulation (induced) of Ras associated with stress
12) Confidence 0.35 Published 2009 Journal Hepatology Section Abstract Doc Link 19739265 Disease Relevance 0.44 Pain Relevance 0.64
The functional role of Ras activation was studied by a single intraperitoneal injection of the neutral sphingomyelinase and farnesyltransferase inhibitor (FTI) manumycin A (1 mg/kg), which lowers induction of Ras-GTP and serum amounts of alanine aminotransferase (ALT).
Positive_regulation (activation) of Ras
13) Confidence 0.35 Published 2009 Journal Hepatology Section Abstract Doc Link 19739265 Disease Relevance 0.48 Pain Relevance 0.64
Farnesyltransferase inhibitors reduce Ras activation and ameliorate acetaminophen-induced liver injury in mice.
Positive_regulation (activation) of Ras in liver associated with paracetamol and injury
14) Confidence 0.35 Published 2009 Journal Hepatology Section Title Doc Link 19739265 Disease Relevance 0.58 Pain Relevance 0.72
These results do not support a definitive aetiological role for H. pylori in RAS, although the possibility that H. pylori may be involved in a small proportion of RAS cases cannot be excluded.
Positive_regulation (proportion) of RAS associated with canker sores
15) Confidence 0.30 Published 2000 Journal J. Oral Pathol. Med. Section Abstract Doc Link 11048967 Disease Relevance 0.97 Pain Relevance 0
Loss of neurofibromin within a cell would thus result in constitutive activation of the Ras signaling pathway, ultimately resulting in cell growth.
Positive_regulation (activation) of Ras
16) Confidence 0.30 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.90 Pain Relevance 0
Observations that the combination of Nf1 and K-ras mutations in mice results in normal cognitive function support the link between an increase in Ras activity and visual-spatial learning deficits.
Positive_regulation (increase) of Ras associated with cognitive disorder
17) Confidence 0.30 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.59 Pain Relevance 0.23
Captopril altered the liver RAS
Positive_regulation (liver) of RAS in liver
18) Confidence 0.29 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 0.64 Pain Relevance 0
Activation of the renin-angiotensin system (RAS) or administration of angiotensin II (AII) will induce water intake.
Positive_regulation (Activation) of RAS
19) Confidence 0.29 Published 1980 Journal Am. J. Physiol. Section Abstract Doc Link 7377376 Disease Relevance 0 Pain Relevance 0
In the liver, the local RAS is up-regulated in response to tissue injury and hypoxia [13,14].
Positive_regulation (regulated) of RAS in liver associated with hypoxia and injury
20) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.28 Pain Relevance 0.06

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