INT216880

Context Info Confidence 0.03 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.06 Pain Relevance 0.25

transport (Apoc4) endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1) cytosol (Hmox1) signal transduction (Hmox1)

Apoc4 (Mus musculus) Hmox1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammatory response 8 92.32 Inflammation 26 88.00 cytokine 26 50.72 Inflammatory mediators 2 5.00 chemokine 1 5.00 Angina 1 5.00 Intracerebroventricular 1 5.00

Disease Link Frequency Relevance Heat Stress 7 99.44 INFLAMMATION 36 91.96 Cardiovascular Disease 7 85.52 Disease 7 84.88 Targeted Disruption 2 69.76 Atherosclerotic Plaque 2 69.20 Atherosclerosis 4 5.00 Adhesions 2 5.00 Necrosis 2 5.00 Cancer 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Hence, one may consider, that induction of HO-1 by apoE4 represents a stress-induced protective response.

apoE4 Positive_regulation (induction) of HO-1 associated with stress

1) Confidence 0.03 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 1.06 Pain Relevance 0.25

General Comments

This test has worked.