INT2169

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Context Info
Confidence 0.48
First Reported 1979
Last Reported 1987
Negated 3
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0
Pain Relevance 4.03

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extracellular region (Penk, Prl)
Anatomy Link Frequency
3rd ventricle 6
Penk (Rattus norvegicus)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 39 100.00 Very High Very High Very High
Morphine 2 98.56 Very High Very High Very High
Opioid 10 96.96 Very High Very High Very High
Dopamine 1 91.84 High High
opiate 9 87.20 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Leu-enkephalin did not affect PRL secretion in vivo.
Leu-enkephalin Neg (not) Regulation (affect) of Localization (secretion) of PRL associated with enkephalin
1) Confidence 0.48 Published 1983 Journal Probl Endokrinol (Mosk) Section Abstract Doc Link 6647430 Disease Relevance 0 Pain Relevance 1.04
Enkephalin alone had no effect on LH or prolactin release in vitro but potentiated the LH response to LHRH.
Enkephalin Neg (no) Regulation (effect) of Localization (release) of prolactin associated with enkephalin
2) Confidence 0.35 Published 1979 Journal Horm. Res. Section Abstract Doc Link 374217 Disease Relevance 0 Pain Relevance 0.74
The effect of beta-endorphin, met-enkephalin and leu-enkephalin on cold-stimulated TSH and prolactin secretion after infusion of the drugs into the 3rd ventricle or into the posterior hypothalamus (PH) was investigated in male rats. beta-endorphin (0.25 microgram/rat, but not 0.05, 0.5 and 1 microgram/rat) increased and met-enkephalin (20 and 100 micrograms/rat) decreased TSH secretion when infused into the 3rd ventricle.
met-enkephalin Regulation (effect) of Localization (secretion) of prolactin in 3rd ventricle associated with enkephalin
3) Confidence 0.12 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 2951956 Disease Relevance 0 Pain Relevance 0.48
The effect of beta-endorphin, met-enkephalin and leu-enkephalin on cold-stimulated TSH and prolactin secretion after infusion of the drugs into the 3rd ventricle or into the posterior hypothalamus (PH) was investigated in male rats. beta-endorphin (0.25 microgram/rat, but not 0.05, 0.5 and 1 microgram/rat) increased and met-enkephalin (20 and 100 micrograms/rat) decreased TSH secretion when infused into the 3rd ventricle.
leu-enkephalin Regulation (effect) of Localization (secretion) of prolactin in 3rd ventricle associated with enkephalin
4) Confidence 0.12 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 2951956 Disease Relevance 0 Pain Relevance 0.48
Leu-enkephalin had no effect on TSH or prolactin secretion at the hypothalamic level.
Leu-enkephalin Neg (no) Regulation (effect) of Localization (secretion) of prolactin associated with enkephalin
5) Confidence 0.12 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 2951956 Disease Relevance 0 Pain Relevance 0.79
The effect of beta-endorphin, met-enkephalin and leu-enkephalin on cold-stimulated TSH and prolactin secretion after infusion of the drugs into the 3rd ventricle or into the posterior hypothalamus (PH) was investigated in male rats. beta-endorphin (0.25 microgram/rat, but not 0.05, 0.5 and 1 microgram/rat) increased and met-enkephalin (20 and 100 micrograms/rat) decreased TSH secretion when infused into the 3rd ventricle.
leu-enkephalin Regulation (effect) of Localization (secretion) of prolactin in 3rd ventricle associated with enkephalin
6) Confidence 0.12 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 2951956 Disease Relevance 0 Pain Relevance 0.48

General Comments

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