INT216932

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Context Info
Confidence 0.38
First Reported 2007
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 4.88
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
retina 3
uterine 2
choroid 1
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 2 94.74 High High
cytokine 69 87.40 High High
Inflammation 163 87.00 High High
tolerance 6 82.80 Quite High
chemokine 3 81.56 Quite High
beta blocker 6 78.40 Quite High
Pain 16 60.40 Quite High
Hyperalgesia 3 28.00 Quite Low
withdrawal 1 24.08 Low Low
iatrogenic 1 12.84 Low Low
Disease Link Frequency Relevance Heat
Ocular Injury 29 99.68 Very High Very High Very High
Coronary Heart Disease 136 99.52 Very High Very High Very High
Reprotox - General 1 3 99.20 Very High Very High Very High
Heart Rate Under Development 59 95.76 Very High Very High Very High
Bacterial Infection 1 93.88 High High
Uveitis 87 92.16 High High
Adhesions 35 90.80 High High
Apoptosis 8 89.68 High High
INFLAMMATION 163 87.00 High High
Toxicity 1 84.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, attenuation of leukocyte recruitment by EPA may result in the decreased production levels of IL-6 and MCP-1 in the retina and choroid.
Spec (may) Positive_regulation (result) of Negative_regulation (decreased) of IL-6 in retina
1) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 1.15 Pain Relevance 0.41
These results raise questions whether IL-6 is locally induced following a penetrating ocular injury and whether an increased level of IL-6 is involved in the abortion of ACAID.
Spec (whether) Positive_regulation (increased) of Spec (whether) Negative_regulation (level) of IL-6 associated with ocular injury and reprotox - general 1
2) Confidence 0.17 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 0.69 Pain Relevance 0.11
In addition, ATP stimulation increased expression levels of IL-4, IL-6, IL-13 and TNF-?
Positive_regulation (increased) of Negative_regulation (levels) of IL-6
3) Confidence 0.17 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.79 Pain Relevance 0.34
Initially, the use of calcium channel blockers (CCB) was not acceptable in heart failure because of their negative contractile effect and the potential risk of uterine hypoperfusion.9,11,23,69,85 Amlodipine has now been shown to improve survival in non-ischemic cardiomyopathy patients.85 Amlodipine resulted in reduction of IL-6 in the Prospective Randomized Amlodipine Survival Evaluation (PRAISE) trial, suggesting a potential role in PPCM management.86 Levosimendan, a calcium sensitizer having vasodilatory properties, improves cardiac contractility in heart failure patients.23,40 Recently, it has been used in a PPCM patient, successfully causing a steady decline of elevated pulmonary capillary wedge pressure (PCWP) and subsequent improvement of CO.40 Because of the lack of safety reports, breast feeding should be avoided in patients taking levosimendan.23

Beta blockers

Positive_regulation (resulted) of Negative_regulation (reduction) of IL-6 in uterine associated with heart rate under development, beta blocker, calcium channel and coronary heart disease
4) Confidence 0.14 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628138 Disease Relevance 0.74 Pain Relevance 0.16
Thus, attenuation of leukocyte recruitment by EPA may result in the decreased production levels of IL-6 and MCP-1 in the retina and choroid.
Spec (may) Positive_regulation (result) of in choroid Negative_regulation (decreased) of IL-6 in retina
5) Confidence 0.13 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 1.15 Pain Relevance 0.41
This may underlie the lack of an additive or synergistic suppression of IL-6 and TNF-?
Spec (may) Positive_regulation (underlie) of Negative_regulation (suppression) of IL-6
6) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.36 Pain Relevance 0.12

General Comments

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