INT216945

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.18
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (P2rx7, Casp1) cytoplasm (P2rx7, Casp1) cell death (P2rx7, Casp1)
transport (P2rx7) cell morphogenesis (P2rx7) intracellular (Casp1)
Anatomy Link Frequency
macrophages 3
P2rx7 (Mus musculus)
Casp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 35 90.68 High High
cytokine 22 87.20 High High
Pain 16 50.00 Quite Low
antagonist 6 39.68 Quite Low
tolerance 1 31.68 Quite Low
chemokine 1 29.40 Quite Low
Neuropathic pain 7 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 8 91.04 High High
INFLAMMATION 48 90.68 High High
Pain 16 50.00 Quite Low
Neuropathic Pain 14 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Neuritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ATP-stimulation of P2X7 results in the rapid activation of caspase-1 in macrophages and the release of mature, biologically active, IL-1?
Positive_regulation (stimulation) of P2X7 in macrophages Positive_regulation (results) of Positive_regulation (activation) of caspase-1 in macrophages
1) Confidence 0.14 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.18 Pain Relevance 0.12

General Comments

This test has worked.

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