INT216974

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Context Info
Confidence 0.16
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.67
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rpsa) structural constituent of ribosome (Rpsa) ribosome (Rpsa)
plasma membrane (Rpsa) nucleus (Rpsa) intracellular (Rpsa)
Anatomy Link Frequency
Th1 cell 1
Rpsa (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 101 99.34 Very High Very High Very High
rheumatoid arthritis 19 96.40 Very High Very High Very High
Pain 2 88.32 High High
Inflammation 37 83.28 Quite High
agonist 33 82.76 Quite High
chemokine 6 76.52 Quite High
iatrogenic 1 69.08 Quite High
Arthritis 25 51.00 Quite High
addiction 1 36.40 Quite Low
antagonist 8 27.16 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 19 96.40 Very High Very High Very High
Pain 2 88.32 High High
Pressure And Volume Under Development 3 87.36 High High
INFLAMMATION 40 83.28 Quite High
Disease 83 83.16 Quite High
Meningoencephalitis 11 69.88 Quite High
Immunization 21 61.88 Quite High
Inflammatory Bowel Disease 2 60.96 Quite High
Autoimmune Disease 3 55.44 Quite High
Arthritis 29 51.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-23 is a heterodimeric protein composed of a p19 subunit and a p40 subunit, whereas IL-12, an important cytokine for Th1 cell differentiation, is formed when the p40 subunit dimerizes with p35 (8).
p40 Binding (subunit) of in Th1 cell associated with cytokine
1) Confidence 0.16 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 0.92 Pain Relevance 0.59
and p35 subunits, and IL-23 is composed of the same p40 subunit together with a
p40 Binding (subunit) of
2) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442897 Disease Relevance 0.44 Pain Relevance 0.19
A related cytokine, IL-23, is composed of the same p40 subunit covalently bound to a unique p19 subunit [53, 54].
p40 Binding (bound) of associated with cytokine
3) Confidence 0.04 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.30 Pain Relevance 0.29

General Comments

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