INT216984

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Context Info
Confidence 0.13
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.81
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rpsa) structural constituent of ribosome (Rpsa) ribosome (Rpsa)
plasma membrane (Rpsa) nucleus (Rpsa) intracellular (Rpsa)
Rpsa (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 25 99.76 Very High Very High Very High
agonist 12 86.84 High High
rheumatoid arthritis 19 72.80 Quite High
cytokine 79 71.96 Quite High
Inflammation 23 39.56 Quite Low
antagonist 8 37.80 Quite Low
chemokine 6 6.24 Low Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Demyelination 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 29 99.76 Very High Very High Very High
Cancer 4 75.00 Quite High
Necrosis 3 75.00 Quite High
Rheumatoid Arthritis 19 72.80 Quite High
INFLAMMATION 24 39.56 Quite Low
Disease 22 5.00 Very Low Very Low Very Low
Immunization 6 5.00 Very Low Very Low Very Low
Severe Combined Immunodeficiency 5 5.00 Very Low Very Low Very Low
Multiple Sclerosis 5 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that at least one of the ways in which TNF regulates Th1/Th17 responses in arthritis is by down-regulating the expression of p40.
Regulation (regulating) of Gene_expression (expression) of p40 associated with arthritis
1) Confidence 0.13 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2571924 Disease Relevance 0.81 Pain Relevance 0.26
It is known from other studies that the p40 and p35 subunits of IL-12 can be regulated independently [64]; lack of coordinated synthesis may help to explain why ATP?
Neg (independently) Regulation (regulated) of Gene_expression (subunits) of p40
2) Confidence 0.05 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0.19

General Comments

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