INT217

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 134
Total Number 139
Disease Relevance 26.83
Pain Relevance 62.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) nucleus (Th)
response to stress (Th) cytoplasm (Th)
Anatomy Link Frequency
brain 8
striatum 8
hypothalamus 6
dopaminergic neurons 5
nerve 5
Th (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 759 100.00 Very High Very High Very High
Ventral tegmentum 136 100.00 Very High Very High Very High
noradrenaline 126 100.00 Very High Very High Very High
Locus ceruleus 93 100.00 Very High Very High Very High
Catecholamine 90 100.00 Very High Very High Very High
Clonidine 50 100.00 Very High Very High Very High
Cholecystokinin 15 100.00 Very High Very High Very High
tetrodotoxin 13 99.98 Very High Very High Very High
Hippocampus 123 99.96 Very High Very High Very High
medulla 30 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 17 99.84 Very High Very High Very High
Restless Legs Syndrome 13 99.70 Very High Very High Very High
Shock 10 99.70 Very High Very High Very High
Parkinson's Disease 299 99.64 Very High Very High Very High
Intellectual Impairment 3 99.60 Very High Very High Very High
INFLAMMATION 201 99.50 Very High Very High Very High
Polycystic Ovary Syndrome 5 99.08 Very High Very High Very High
Injury 25 98.96 Very High Very High Very High
Hypertension 11 98.90 Very High Very High Very High
Toxocariasis 14 98.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Repeated treatment of rats with antidepressant drugs down-regulates tyrosine hydroxylase (TH) in the locus coeruleus (LC).
Negative_regulation (down-regulates) of TH in locus coeruleus associated with antidepressant and locus ceruleus
1) Confidence 0.59 Published 2004 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 15228643 Disease Relevance 0 Pain Relevance 0.42
Repeated treatment of rats with antidepressant drugs down-regulates tyrosine hydroxylase (TH) in the locus coeruleus (LC).
Negative_regulation (down-regulates) of tyrosine hydroxylase in locus coeruleus associated with antidepressant and locus ceruleus
2) Confidence 0.59 Published 2004 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 15228643 Disease Relevance 0 Pain Relevance 0.42
In the sympathectomised eyes there was a marked depletion of TH and increase in CGRP immunoreactivity while in tissue subjected to sensory denervation the reverse was found, raised presence of TH and absence of CGRP-immunostaining.
Negative_regulation (depletion) of TH in eyes
3) Confidence 0.59 Published 1988 Journal Curr. Eye Res. Section Abstract Doc Link 2903010 Disease Relevance 0 Pain Relevance 0.15
Renal nerve activity, as measured by norepinephrine turnover (inhibition of tyrosine hydroxylase by alpha-methyl-p-tyrosine), was not different between conscious fed or fasted rats and increased to the same extent in fed and fasted rats when anesthetized and surgically prepared.
Negative_regulation (inhibition) of tyrosine hydroxylase in Renal nerve
4) Confidence 0.59 Published 1990 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2328455 Disease Relevance 0.08 Pain Relevance 0
Morphine was found to counteract the NA depletion induced by tyrosine hydroxylase inhibition in neonate rats, indicating that morphine reduces NA turnover.
Negative_regulation (inhibition) of tyrosine hydroxylase associated with noradrenaline and morphine
5) Confidence 0.59 Published 1982 Journal Med. Biol. Section Abstract Doc Link 6128445 Disease Relevance 0 Pain Relevance 1.22
The reduction in TH mRNA was blocked by cycloheximide consistent with a protein-dependent mechanism.
Negative_regulation (reduction) of TH mRNA
6) Confidence 0.59 Published 2007 Journal Brain Res. Section Abstract Doc Link 17174279 Disease Relevance 0 Pain Relevance 0.18
Significantly, butyrate-dependent decreases in TH mRNA were also reflected in a reduction in TH protein.
Negative_regulation (decreases) of TH mRNA
7) Confidence 0.59 Published 2007 Journal Brain Res. Section Abstract Doc Link 17174279 Disease Relevance 0 Pain Relevance 0.20
However, at higher physiological concentrations (6 mM), TH mRNA levels are significantly reduced while ppEnk mRNA transcripts remained elevated.
Negative_regulation (reduced) of TH mRNA
8) Confidence 0.59 Published 2007 Journal Brain Res. Section Abstract Doc Link 17174279 Disease Relevance 0 Pain Relevance 0.20
Thirty days after the last ECS we observed a decrease of TH activity in the amygdala and of TH-mRNA amount in the ventral tegmental area.
Negative_regulation (decrease) of TH in ventral associated with ventral tegmentum, shock and amygdala
9) Confidence 0.58 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 1968090 Disease Relevance 0.50 Pain Relevance 0.93
Four weeks after 6-OHDA treatment, TH mRNA levels were reduced below the limits of sensitivity of the assay (1 pg/ug RNA) in ipsilateral SN while the levels of TH mRNA in contralateral SN (4.8 pg/ug RNA) did not differ from that in sham treated animals.
Negative_regulation (reduced) of TH mRNA associated with substantia nigra
10) Confidence 0.58 Published 1993 Journal Life Sci. Section Abstract Doc Link 8097862 Disease Relevance 0 Pain Relevance 0.25
Endogenous opioid peptides contribute to suckling-induced prolactin release by suppressing tyrosine hydroxylase activity and messenger ribonucleic acid levels in tuberoinfundibular dopaminergic neurons.
Negative_regulation (suppressing) of tyrosine hydroxylase in dopaminergic neurons associated with endogenous opioid
11) Confidence 0.58 Published 1998 Journal Endocrinology Section Title Doc Link 9607794 Disease Relevance 0.05 Pain Relevance 0.46
TH immunoreactivity in the NTS/VLM was increased 90 min after morphine withdrawal, whereas there was a decrease in TH levels in the PVN at the same time point.
Negative_regulation (decrease) of TH in VLM associated with toxocariasis, withdrawal and morphine
12) Confidence 0.58 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12534973 Disease Relevance 0.53 Pain Relevance 1.56
The basal firing rate was not modified by either a single dose or repeated doses of MDMA, although the latter produced a shift to the right in the dose-response curve for clonidine-induced inhibition of the firing rate (ED(50) increased by 59%) and a reduction in tyrosine hydroxylase activity (20%) in the hippocampus.
Negative_regulation (reduction) of tyrosine hydroxylase in hippocampus associated with hippocampus and clonidine
13) Confidence 0.57 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12536039 Disease Relevance 0 Pain Relevance 0.35
Both fumes also caused loss of tyrosine hydroxylase (TH) protein in the striatum (~20%) and midbrain (~30%) by 1 day post-exposure.
Negative_regulation (loss) of tyrosine hydroxylase in midbrain associated with midbrain
14) Confidence 0.56 Published 2010 Journal Arch. Toxicol. Section Abstract Doc Link 20224926 Disease Relevance 0.58 Pain Relevance 0.31
Both fumes also caused loss of tyrosine hydroxylase (TH) protein in the striatum (~20%) and midbrain (~30%) by 1 day post-exposure.
Negative_regulation (loss) of TH in midbrain associated with midbrain
15) Confidence 0.56 Published 2010 Journal Arch. Toxicol. Section Abstract Doc Link 20224926 Disease Relevance 0.58 Pain Relevance 0.31
After three weeks of chronic oral administration of clonidine, tyrosine hydroxylase (TOH) activity was unchanged in superior cervical ganglia and locus coeruleus, but was reduced (45%) in the celiac ganglia.
Negative_regulation (reduced) of tyrosine hydroxylase in superior associated with locus ceruleus and clonidine
16) Confidence 0.56 Published 1978 Journal Eur. J. Pharmacol. Section Abstract Doc Link 30636 Disease Relevance 0.19 Pain Relevance 0.66
After inhibition of tyrosine hydroxylase by pretreatment with alpha-methyl-p-tyrosine (250 mg/kg, intraperitoneal injection), most of the increase persisted.
Negative_regulation (inhibition) of tyrosine hydroxylase
17) Confidence 0.54 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 1968962 Disease Relevance 0 Pain Relevance 0.59
Consistent with previous electrophysiological data, IBMX also accelerates the disappearance of NE after inhibition of tyrosine-3-monooxygenase.
Negative_regulation (inhibition) of tyrosine-3-monooxygenase
18) Confidence 0.54 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6194283 Disease Relevance 0.06 Pain Relevance 0.47
TH activity decreased after morphine treatment in some areas such as the median eminence-arcuate region (ME-ARC), the amygdala, and the thalamus, showing statistically significant change.
Negative_regulation (decreased) of TH in amygdala associated with aids-related complex, thalamus, amygdala and morphine
19) Confidence 0.54 Published 1998 Journal Brain Res. Bull. Section Abstract Doc Link 9766393 Disease Relevance 0.25 Pain Relevance 0.80
We found a decrease in tyrosine hydroxylase (TH) activity and in the content of dopamine (DA) in the anterior hypothalamus after 2 mo of EV injection, whereas dopamine-beta-hydroxylase (D beta H) was increased without changes in NE content.
Negative_regulation (decrease) of TH in hypothalamus associated with dopamine
20) Confidence 0.53 Published 1995 Journal Biol. Reprod. Section Abstract Doc Link 7711208 Disease Relevance 0.39 Pain Relevance 0.19

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