INT217004

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.15
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2RY6) signal transducer activity (P2RY6)
Anatomy Link Frequency
T-cells 4
blood vessels 2
P2RY6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 80 99.60 Very High Very High Very High
cytokine 146 99.22 Very High Very High Very High
agonist 46 74.72 Quite High
antagonist 54 63.32 Quite High
chemokine 8 31.24 Quite Low
adenocard 28 5.00 Very Low Very Low Very Low
noradrenaline 18 5.00 Very Low Very Low Very Low
Migraine 16 5.00 Very Low Very Low Very Low
rheumatoid arthritis 14 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 80 99.60 Very High Very High Very High
Stress 34 98.94 Very High Very High Very High
Inflammatory Bowel Disease 4 98.56 Very High Very High Very High
Increased Venous Pressure Under Development 122 94.96 High High
Disease 48 91.28 High High
Neointima 10 86.72 High High
Targeted Disruption 32 86.56 High High
Cv Unclassified Under Development 18 63.28 Quite High
Hypertension 48 61.40 Quite High
Diabetes Mellitus 22 57.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As such, P2Y6 receptor expression on T-cells may be upregulated at sites of inflammation and/or T-cells expressing this receptor may be preferentially recruited to these sites.
Positive_regulation (upregulated) of Gene_expression (expression) of P2Y6 in T-cells associated with inflammation
1) Confidence 0.28 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.53 Pain Relevance 0.43
However, tissue sections obtained from patients with inflammatory bowel disease are reported to contain T-cells within inflammatory lesions possessing enhanced expression of the P2Y6 receptor [51].
Positive_regulation (enhanced) of Gene_expression (expression) of P2Y6 in T-cells associated with inflammation
2) Confidence 0.28 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.54 Pain Relevance 0.43
In intact human blood vessels examined in vitro, shear stress decreased contractile P2X1 receptor expression, but increased the expression of mitogenic P2Y2 and P2Y6 receptors in VSMC [151].
Positive_regulation (increased) of Gene_expression (expression) of P2Y6 in blood vessels associated with stress
3) Confidence 0.25 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.48 Pain Relevance 0.03
Growth factors, cytokines and interestingly also ATP are potent stimulators of P2Y2 receptor expression [146, 147].
Positive_regulation (stimulators) of Gene_expression (expression) of P2Y2 receptor associated with cytokine
4) Confidence 0.25 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.60 Pain Relevance 0.05

General Comments

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