INT217018

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.34
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2RX1) transport (P2RX1) plasma membrane (P2RX1)
protein complex (P2RX1)
P2RX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 68 99.84 Very High Very High Very High
Inflammatory response 3 97.08 Very High Very High Very High
agonist 45 94.88 High High
sodium channel 1 84.88 Quite High
Inflammation 19 80.80 Quite High
Pain 3 76.48 Quite High
antagonist 11 70.40 Quite High
potassium channel 3 69.20 Quite High
adenocard 1 26.40 Quite Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 19 96.72 Very High Very High Very High
Contact Dermatitis 1 85.56 High High
Pain 3 76.48 Quite High
Shock 3 21.60 Low Low
Disease 12 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 6 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall the results show that recycling plays an important role in the regulation of P2X1 receptor responsiveness.
Regulation (role) of Regulation (regulation) of P2X1
1) Confidence 0.26 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.09
This study shows that although P2X1-4 receptors were found in lipid rafts, this association only plays an important role in regulation of P2X1 receptors under basal conditions.
Regulation (role) of Regulation (regulation) of P2X1
2) Confidence 0.25 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0
This suggests that additional parts of the receptor play a substantial role in lipid raft regulation of the P2X1 receptor.
Regulation (role) of Regulation (regulation) of P2X1 receptor
3) Confidence 0.25 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.03
P2X receptor-dependent regulation of cytokine production
Regulation (dependent) of Regulation (regulation) of P2X receptor associated with cytokine
4) Confidence 0.14 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.34 Pain Relevance 0.41

General Comments

This test has worked.

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