INT217042

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.03
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (TNF) extracellular matrix organization (TNF) DNA binding (IRF6)
cytoplasm (IRF6) cytosol (IRF6) signal transduction (TNF)
Anatomy Link Frequency
Hepatocytes 1
leukocytes 1
IRF6 (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 56 100.00 Very High Very High Very High
Inflammatory stimuli 36 100.00 Very High Very High Very High
Inflammation 198 96.12 Very High Very High Very High
Inflammatory response 74 94.92 High High
dexamethasone 5 88.80 High High
cytokine 75 85.84 High High
corticosteroid 56 79.00 Quite High
tolerance 8 71.36 Quite High
Pain 3 69.84 Quite High
Bile 5 64.64 Quite High
Disease Link Frequency Relevance Heat
Adhesions 8 100.00 Very High Very High Very High
Alzheimer's Dementia 2 100.00 Very High Very High Very High
Acute-phase Reaction 1 98.28 Very High Very High Very High
INFLAMMATION 285 96.12 Very High Very High Very High
Cancer 6 93.20 High High
Death 19 92.80 High High
Disease 25 91.48 High High
Fever 3 75.80 Quite High
Neuropathic Pain 2 70.44 Quite High
Pain 3 69.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LPS is known to stimulate TNF?
LPS Positive_regulation (stimulate) of TNF
1) Confidence 0.27 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2525633 Disease Relevance 0.77 Pain Relevance 0.47
These in silico results lie in agreement with studies [31] that suggest a dose-dependent decrease in LPS-induced TNF in peripheral human blood leukocytes that are exposed to hydrocortisone infusion.
LPS Positive_regulation (induced) of TNF in leukocytes associated with inflammatory stimuli
2) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.49 Pain Relevance 0.59
Hepatocytes express TLR4, and respond to LPS by inducing serum amyloid A, cytochrome P450, superoxide dismutase activity, adhesion molecule, TNF-?
LPS Positive_regulation (inducing) of TNF in Hepatocytes associated with alzheimer's dementia, agonist and adhesions
3) Confidence 0.07 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.53 Pain Relevance 0.43
Moreover, ATP can negatively regulate Toll-like receptor signalling, suppress LPS-induced MCP-1 and TNF-?
LPS Positive_regulation (induced) of TNF
4) Confidence 0.01 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096763 Disease Relevance 1.24 Pain Relevance 0.47

General Comments

This test has worked.

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