INT217067

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 3.09
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK8) nucleoplasm (MAPK8) mitochondrion (MAPK8)
nucleus (MAPK8) response to stress (MAPK8) cytoplasm (MAPK8)
Anatomy Link Frequency
macrophages 2
embryos 2
Caco-2 2
epithelial cells 2
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 86 94.00 High High
Nicotine 96 93.20 High High
cytokine 33 92.96 High High
bradykinin 41 90.08 High High
Inflammatory response 20 72.52 Quite High
agonist 13 50.00 Quite Low
depression 1 46.88 Quite Low
Hsan 8 40.16 Quite Low
Nerve growth factor 2 37.04 Quite Low
chemokine 22 30.80 Quite Low
Disease Link Frequency Relevance Heat
Vibrio Infection 3 99.34 Very High Very High Very High
Death 109 98.94 Very High Very High Very High
Stress 119 98.80 Very High Very High Very High
Nicotine Addiction 12 94.80 High High
INFLAMMATION 105 94.00 High High
Familial Dysautonomia 30 92.68 High High
Infection 64 91.00 High High
Skin Cancer 51 84.40 Quite High
Apoptosis 62 78.64 Quite High
Injury 55 66.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further validate whether the increased activation of JNK-mediated downregulation of VEGF-C is dependent on podoplanin, the levels of phosphorylated JNK and VEGF-C mRNA were examined using siRNA methods.
Spec (whether) Regulation (dependent) of Spec (whether) Positive_regulation (activation) of JNK
1) Confidence 0.45 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.05 Pain Relevance 0
Taken together, these findings suggested that the podoplanin-mediated increase in the level of activated JNK was a downregulation signal for the VEGF-C gene in EBC-1 cells.
Regulation (downregulation) of Positive_regulation (increase) of JNK
2) Confidence 0.33 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.08 Pain Relevance 0
Taken together, these findings suggested that the podoplanin-mediated increase in the level of activated JNK was a downregulation signal for the VEGF-C gene in EBC-1 cells.
Regulation (downregulation) of Positive_regulation (activated) of JNK
3) Confidence 0.33 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.08 Pain Relevance 0
In early Xenopus embryos, high level of nuclear JNK negatively regulates the canonical Wnt/?
Regulation (regulates) of Positive_regulation (level) of JNK in embryos
4) Confidence 0.15 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.26 Pain Relevance 0
The whole process depends on the activation of JNK- and PDE4-related intracellular signal pathways Thus, our findings might provide new therapeutic targets for future treatment of tobacco smoke-associated AHR.


Regulation (depends) of Positive_regulation (activation) of JNK associated with nicotine addiction
5) Confidence 0.12 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.09 Pain Relevance 0.30
B will act to prevent cell death by a number of mechanisms, some of them potentially affecting ROS-mediated sustained JNK activation, such as specifically the reported up-regulation of SOD-2 (that is, the mitochondrial SOD isoform), in TNF-dependent cell death [210].
Regulation (affecting) of Positive_regulation (activation) of JNK associated with death
6) Confidence 0.08 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.08 Pain Relevance 0
The CtxB cholera toxin from Vibrio cholerae down-regulates p38 and JNK activation in macrophages leading to suppression of production of TNF?
Regulation (regulates) of Positive_regulation (activation) of JNK in macrophages associated with vibrio infection
7) Confidence 0.07 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC3022711 Disease Relevance 0.67 Pain Relevance 0.13
TTSS1 of V. parahaemolyticus is responsible for activation of JNK, p38 and ERK in epithelial cells
Regulation (responsible) of Positive_regulation (activation) of JNK in epithelial cells
8) Confidence 0.07 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC3022711 Disease Relevance 0 Pain Relevance 0
Furthermore, studies in yeast suggest that the Elongator complex is involved in exocytosis and tRNA modification and studies in mammalian cells implicate IKAP as a scaffold protein involved in cytoplasmic JNK activation in response to extracellular stress.
Regulation (involved) of Positive_regulation (activation) of JNK associated with stress
9) Confidence 0.05 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2098750 Disease Relevance 0.68 Pain Relevance 0
The results suggest that activation of JNK and ERK, but not p38, is involved in the ability of V. parahaemolyticus to be cytotoxic to the Caco-2 cells.
Regulation (involved) of Positive_regulation (activation) of JNK in Caco-2
10) Confidence 0.04 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC3022711 Disease Relevance 0.09 Pain Relevance 0

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