INT217072

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 6.15
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Acsm3) molecular_function (Acsm3) cellular_component (Acsm3)
ligase activity (Acsm3) biological_process (Acsm3) lipid metabolic process (Acsm3)
Anatomy Link Frequency
artery 1
Acsm3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 141 100.00 Very High Very High Very High
Inflammatory mediators 16 98.36 Very High Very High Very High
drug abuse 21 98.24 Very High Very High Very High
alcohol 100 88.00 High High
depression 21 85.24 High High
Inflammation 39 75.00 Quite High
cytokine 23 65.44 Quite High
Inflammatory marker 1 58.48 Quite High
chemokine 23 32.96 Quite Low
addiction 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Subarachnoid Hemorrhage 133 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 10 99.92 Very High Very High Very High
Drug Dependence 108 99.84 Very High Very High Very High
Dysthymic Disorder 6 99.74 Very High Very High Very High
Heart Rate Under Development 14 99.40 Very High Very High Very High
Affective Disorder 45 99.20 Very High Very High Very High
INFLAMMATION 45 98.36 Very High Very High Very High
Hemorrhage 6 95.72 Very High Very High Very High
Alcoholic Fatty Liver 2 94.40 High High
Increased Venous Pressure Under Development 23 91.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ALI in SAH may be predisposed by neurogenic pulmonary edema (NPE) and inflammatory mediators.
Negative_regulation (predisposed) of SAH associated with heart rate under development, inflammatory mediators, adult respiratory distress syndrome and cva
1) Confidence 0.29 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2945141 Disease Relevance 1.55 Pain Relevance 0.53
Betaine also prevented the decrease in S-adenosylthomocysteine (SAH) [9].
Negative_regulation (decrease) of SAH
2) Confidence 0.17 Published 2010 Journal Genes Nutr Section Body Doc Link PMC2988994 Disease Relevance 0.52 Pain Relevance 0.17
The main findings of this study are that (1) vascular inflammatory mediators were induced after SAH and could be remarkably repressed when treated with melatonin; (2) the increased lipid peroxidation in the artery tissues could be significantly downregulated after melatonin injections following experimental SAH; (3) after melatonin administration, the postSAH reduced antioxidative status was ameliorated in this two-hemorrhage model; (4) in agreement with the previous research [5], treatment with melatonin prevented cerebral vasospasm of the basilar arteries in rabbits.
Negative_regulation (downregulated) of SAH in artery associated with inflammatory mediators, cva and increased venous pressure under development
3) Confidence 0.14 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821769 Disease Relevance 1.30 Pain Relevance 0.56
There is also no consistent answer to the very important question of whether recovery from SUD leads to a significant reduction in SA in prospective studies [17,20].
Spec (whether) Negative_regulation (reduction) of SA associated with drug dependence
4) Confidence 0.07 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2098764 Disease Relevance 0.71 Pain Relevance 0.11
To prevent SA, treatment of both affective disorders and substance abuse is important.



Negative_regulation (prevent) of SA associated with affective disorder and drug abuse
5) Confidence 0.05 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Abstract Doc Link PMC2098764 Disease Relevance 0.85 Pain Relevance 0.15
Together, the cross sectional and prospective parts of the study indicate that affective disorders, especially the chronic, long lasting dysthymic disorder, are stable predictors of SA in SUD clients, a finding supported by the research literature.
Negative_regulation (predictors) of SA associated with drug dependence, dysthymic disorder and affective disorder
6) Confidence 0.05 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2098764 Disease Relevance 1.23 Pain Relevance 0.08

General Comments

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