INT217082

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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.36
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Bmpr1a) plasma membrane (Bmpr1a) kinase activity (Bmpr1a)
Anatomy Link Frequency
chondrocyte 1
hindbrain 1
Bmpr1a (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 91 92.36 High High
fibrosis 2 68.40 Quite High
narcan 7 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
Locus ceruleus 3 5.00 Very Low Very Low Very Low
parabrachial 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
fifth nerve 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 96 92.36 High High
Fibrosis 2 68.40 Quite High
Disease 12 61.92 Quite High
Birth Weight 2 54.32 Quite High
Disease Progression 1 22.80 Low Low
Frailty 1 19.84 Low Low
Targeted Disruption 8 18.40 Low Low
Apnoea 17 5.00 Very Low Very Low Very Low
Aging 13 5.00 Very Low Very Low Very Low
Hypertrophy 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
General blocking of the Smad1/5/8 pathway using kinase blockers that inhibit the activity of ALK1, ALK2, ALK3 and ALK6 is an alternative option to stop chondrocyte aberrant differentiation.
Negative_regulation (inhibit) of ALK3 in chondrocyte
1) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.30 Pain Relevance 0.12
In the hindbrain, this combination behaves as a hypomorphic mutation, resulting in a severe reduction in, but not elimination of, r3, and a slight reduction of r5 (Figure 4).


Negative_regulation (reduction) of r5 in hindbrain
2) Confidence 0.01 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.05 Pain Relevance 0

General Comments

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