INT217083

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.16
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Rrm2) oxidoreductase activity (Rrm2) cytoplasm (Rrm2)
Anatomy Link Frequency
brain 1
Rrm2 (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 246 77.52 Quite High
narcan 21 70.56 Quite High
parabrachial 9 61.60 Quite High
Locus ceruleus 9 53.44 Quite High
Inflammation 62 5.00 Very Low Very Low Very Low
medulla 12 5.00 Very Low Very Low Very Low
fifth nerve 6 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 29 99.54 Very High Very High Very High
Sprains And Strains 178 98.64 Very High Very High Very High
Disease 320 94.20 High High
Inflammatory Bowel Disease 357 94.12 High High
Apnoea 51 86.16 High High
Apoptosis 42 83.48 Quite High
Pathologic Neovascularization 2 80.56 Quite High
Acute Liver Failure 22 79.56 Quite High
Cancer 15 77.76 Quite High
Pathologic Processes 2 71.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The r2::Cre transgenic line allows selective expression of Cre in r2 and its derivatives, as described in [45].
Gene_expression (expression) of r2 associated with targeted disruption
1) Confidence 0.47 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.19 Pain Relevance 0
MP and SD carried out the brain sectioning and EGFP staining of r2 specific Hoxa2-expressing cell progenies and FMR helped in the mutant analysis.
Gene_expression (sectioning) of r2 in brain
2) Confidence 0.47 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.18 Pain Relevance 0
Overexpression of R2 in the porcine EC led to actin reorganization, chemotaxis, and mitogenesis in response to VEGF, though R1 expression in the same cells had a minimal effect in vitro [31].
Gene_expression (Overexpression) of R2
3) Confidence 0.37 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2933582 Disease Relevance 0.57 Pain Relevance 0
We analyzed the distribution of Enhanced Green Fluorescent Protein positive (EGFP+) cells in knock-in mice in which EGFP expression was selectively induced in r2-derived Hoxa2 expressing cells upon Cre-mediated recombination, by mating the Hoxa2EGFP(lox-neo-lox) knock-in allele with a r2-specific Cre transgenic line [12] (Figure 6a, b, d, e, g; see also Materials and methods).
Gene_expression (expressing) of r2 associated with targeted disruption
4) Confidence 0.37 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.45 Pain Relevance 0.15
r2 values of Pearson's correlations between pulse rate recorded in resting state or under drug treatment were 0.74 for ate vs ctr (p?
Gene_expression (values) of r2
5) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722085 Disease Relevance 0.66 Pain Relevance 0
0.38) and with the tagging SNP rs224217 (r2?
Gene_expression (tagging) of r2
6) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 0.64 Pain Relevance 0.10
1.00) and in high LD with tagging SNP rs224217 (r2?
Gene_expression (tagging) of r2
7) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 0.60 Pain Relevance 0.11
0.38) and with the tagging SNP rs224217 (r2?
Gene_expression (with) of r2
8) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 0.64 Pain Relevance 0.10
0.00277 and r2?
Gene_expression (0.00277) of r2
9) Confidence 0.10 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.09 Pain Relevance 0
0.00131 (r2?
Gene_expression (0.00131) of r2
10) Confidence 0.10 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.14 Pain Relevance 0

General Comments

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