INT217088

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.49
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr2) intracellular (Egr2) DNA binding (Egr2)
ligase activity (Egr2) cytoplasm (Egr2)
Anatomy Link Frequency
neuronal 2
respiratory 2
Egr2 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 3 86.72 High High
Hippocampus 30 80.48 Quite High
Opioid 2 78.92 Quite High
narcan 14 48.92 Quite Low
dopamine receptor 6 46.72 Quite Low
opiate 6 44.08 Quite Low
withdrawal 6 43.52 Quite Low
amygdala 6 37.92 Quite Low
long-term potentiation 24 34.48 Quite Low
fifth nerve 4 24.08 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 41 99.48 Very High Very High Very High
Cognitive Disorder 60 91.20 High High
Anxiety Disorder 60 87.32 High High
Convulsion 12 84.80 Quite High
Apnoea 34 83.68 Quite High
Neurodegenerative Disease 6 79.36 Quite High
Appetite Loss 24 73.12 Quite High
Lifespan 3 59.16 Quite High
Death 4 57.52 Quite High
Shock 60 55.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Detection of Cre-mediated deletion of the Egr2 gene
Positive_regulation (mediated) of Gene_expression (deletion) of Egr2
1) Confidence 0.50 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.06 Pain Relevance 0.04
Our Western blot analyses also suggest that the normal performance of Egr2-deficient mice and the facilitation observed in certain tasks is not due to a compensatory overexpression, or a greater inducibility of the Egr family members known to be involved in learning and memory.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Egr2
2) Confidence 0.50 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.82 Pain Relevance 0.04
Generation of Egr2 conditional knock-out mice and genotyping
Positive_regulation (Generation) of Gene_expression (Generation) of Egr2 associated with targeted disruption
3) Confidence 0.50 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.24 Pain Relevance 0
Krox20 expression in r3 was found necessary for the non-cell autonomous induction of a neuronal rhythm controller from r4 [27].
Positive_regulation (necessary) of Gene_expression (expression) of Krox20 in neuronal
4) Confidence 0.45 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.37 Pain Relevance 0.08
Hoxa2 inactivation, affecting the r1-r2 region and respiratory amplitude, did not severely perturb respiratory rhythm that requires normal Krox20 and Hoxa1 expression in the r3-r5 region [26].
Positive_regulation (requires) of Gene_expression (expression) of Krox20 in respiratory
5) Confidence 0.45 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0 Pain Relevance 0

General Comments

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