INT217091

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 4.12
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Rrm2) oxidoreductase activity (Rrm2) cytoplasm (Rrm2)
Anatomy Link Frequency
trigeminal nerve 1
Rrm2 (Mus musculus)
Pain Link Frequency Relevance Heat
fifth nerve 4 99.68 Very High Very High Very High
depression 42 90.92 High High
narcan 14 71.00 Quite High
parabrachial 6 59.60 Quite High
Locus ceruleus 6 51.44 Quite High
nud 2 46.68 Quite Low
Pain 6 42.68 Quite Low
psoriasis 4 26.60 Quite Low
Arthritis 4 26.16 Quite Low
medulla 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 14 99.00 Very High Very High Very High
Apoptosis 108 97.72 Very High Very High Very High
Injury 16 97.72 Very High Very High Very High
Acute Liver Failure 88 96.60 Very High Very High Very High
Anxiety Disorder 46 91.36 High High
Depression 52 90.92 High High
Apnoea 34 86.60 High High
Somatoform Disorder 128 73.76 Quite High
Congenital Anomalies 10 64.72 Quite High
Cancer 12 62.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
R2 activation led to an increase in proliferation of EC after hepatic injury, that in turn, led to EC regeneration.
Positive_regulation (activation) of R2 associated with injury
1) Confidence 0.33 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2933582 Disease Relevance 0.57 Pain Relevance 0
We analyzed the distribution of Enhanced Green Fluorescent Protein positive (EGFP+) cells in knock-in mice in which EGFP expression was selectively induced in r2-derived Hoxa2 expressing cells upon Cre-mediated recombination, by mating the Hoxa2EGFP(lox-neo-lox) knock-in allele with a r2-specific Cre transgenic line [12] (Figure 6a, b, d, e, g; see also Materials and methods).
Positive_regulation (induced) of r2 associated with targeted disruption
2) Confidence 0.31 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.45 Pain Relevance 0.15
As shown recently, Hoxa2 is required in r2-r3 for trigeminal nerve pathfinding at early stages and axonal arborization of afferents at later stages [13].
Positive_regulation (required) of r2 in trigeminal nerve associated with fifth nerve
3) Confidence 0.31 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.06 Pain Relevance 0.05
The anti-R1 and anti-R2 specific neutralizing monoclonal antibodies (R1-mAb and R2-mAb, respectively) were generated as described previously [20].
Positive_regulation (generated) of R2-mAb
4) Confidence 0.26 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2933582 Disease Relevance 0.18 Pain Relevance 0
In addition to VEGF administration, stimulation of VEGFRs, especially R2, such as during gene delivery, would be an alternative new therapeutic strategy for AHF in the future.


Positive_regulation (stimulation) of R2 associated with acute liver failure
5) Confidence 0.24 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2933582 Disease Relevance 0.43 Pain Relevance 0
The correlation between the number of symptoms reported at base-line on the full list of symptoms and after a 6-month period for a sample of 24 persons was r = 0.67, increasing to 0.69 in the R-SOMS-2.
Positive_regulation (increasing) of R-SOMS-2
6) Confidence 0.23 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2894757 Disease Relevance 1.38 Pain Relevance 0.30
R2 activation not only mediated SEC proliferation but also resulted in induction of a subset of hepatotrophic genes [41].
Positive_regulation (activation) of R2
7) Confidence 0.22 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2933582 Disease Relevance 0.53 Pain Relevance 0
An overall sensitivity of 86.0% and specificity of 95.5% was attained both for SOMS-2 and R-SOMS-2 at FCSE, and the corresponding values at self-report are 57.9% and 88.2% for the former, decreasing slightly the sensitivity and increasing the specificity for the R-SOMS-2 symptoms list, 56.1% and 93.6%.
Positive_regulation (increasing) of R-SOMS-2
8) Confidence 0.18 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2894757 Disease Relevance 0.51 Pain Relevance 0.09

General Comments

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