INT217096

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.23
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr2) intracellular (Egr2) DNA binding (Egr2)
ligase activity (Egr2) cytoplasm (Egr2)
Anatomy Link Frequency
forebrain 2
respiratory 2
neurons 1
jaw 1
Egr2 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 3 85.52 High High
Central nervous system 11 84.60 Quite High
Hippocampus 50 83.92 Quite High
narcan 28 73.88 Quite High
Eae 10 48.88 Quite Low
long-term potentiation 40 48.84 Quite Low
Demyelination 6 44.08 Quite Low
withdrawal 10 37.88 Quite Low
opiate 10 37.44 Quite Low
dopamine receptor 10 36.56 Quite Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 100 98.92 Very High Very High Very High
Appetite Loss 40 98.46 Very High Very High Very High
Apnoea 68 97.92 Very High Very High Very High
Targeted Disruption 74 97.36 Very High Very High Very High
Congenital Anomalies 30 89.92 High High
Ganglion Cysts 3 85.52 High High
Anxiety Disorder 100 83.76 Quite High
Body Weight 14 82.40 Quite High
Neurodegenerative Disease 12 81.56 Quite High
Attention Deficit Hyperactivity Disorder 5 78.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present findings also provide the first evidence that impaired forebrain Egr2 function may facilitate certain forms of learning and memory.
Negative_regulation (impaired) of Egr2 in forebrain
1) Confidence 0.58 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.25 Pain Relevance 0.04
In these mice Egr2 is therefore inactivated in forebrain neurons, whereas one allele is preserved in the rest of the body.
Negative_regulation (inactivated) of Egr2 in forebrain
2) Confidence 0.43 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.23 Pain Relevance 0.08
In contrast, in the cKO mice, presence of the deleted allele was attested by this analysis in all these tissues (Figure 1B), establishing that recombination occurred as expected, leading to complete inactivation of Egr2 in at least part of the cells.


Negative_regulation (inactivation) of Egr2
3) Confidence 0.43 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.23 Pain Relevance 0
Our results provide evidence that none of the forms of learning examined are impaired in Egr2-deficient mice.
Negative_regulation (impaired) of Egr2
4) Confidence 0.43 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.62 Pain Relevance 0.03
We found that inactivation of either Hoxa2 or Krox20 impairs the rhythmic control of the jaw opening in agreement with HOXA2-dependent trigeminal defects and direct regulation of Hoxa2 by KROX20 in r3.
Negative_regulation (inactivation) of Krox20 in jaw
5) Confidence 0.42 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0 Pain Relevance 0
Therefore, partial impairment of Krox20 function, resulting in a severe reduction of r3, is compatible with a normal control of the respiratory rhythm at birth and does not reproduce the Hoxa2 null phenotype characterized by the absence of a transient decrease in tidal volume around birth.
Negative_regulation (impairment) of Krox20 in respiratory
6) Confidence 0.42 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.30 Pain Relevance 0
Taken together, these results establish that Hoxa2 does not mediate the Krox20 null respiratory phenotype in r3 since Hoxa2 null mutation does not reproduce Krox20 null mutation phenotypic traits.
Neg (not) Negative_regulation (reproduce) of Krox20 in respiratory
7) Confidence 0.42 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.44 Pain Relevance 0
The phenotype of Egr1 mutant mice is characterised by profound deficits restricted to long-term, but not short-term memory in several tasks (Bozon et al., 2002; Bozon et al., 2003b; Jones et al., 2001), including spatial learning, conditioned taste aversion and object recognition tasks for which we found no specific impairment when Egr2 is eliminated from forebrain neurons.
Negative_regulation (eliminated) of Egr2 in neurons associated with appetite loss and cognitive disorder
8) Confidence 0.38 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.78 Pain Relevance 0
Previous observations [36] have shown that the anti-apneic activity abolished in Krox20-/- and Hoxa1-/- mutants is preserved in kreisler mutants lacking r5.
Negative_regulation (abolished) of Krox20
9) Confidence 0.36 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.07 Pain Relevance 0.04
In addition, levels of the transcription factors Oct-6 and Krox-20 remain low in these co-cultures.
Negative_regulation (low) of Krox-20
10) Confidence 0.16 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0.31 Pain Relevance 0.04

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