INT217097

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Context Info
Confidence 0.62
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.40
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr2) intracellular (Egr2) DNA binding (Egr2)
ligase activity (Egr2) cytoplasm (Egr2)
Anatomy Link Frequency
jaw 1
Tooth 1
Schwann cells 1
Egr2 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 14 93.96 High High
Pyramidal cell 4 82.36 Quite High
Hippocampus 40 79.72 Quite High
Central nervous system 8 69.24 Quite High
medulla 12 59.24 Quite High
amygdala 8 56.60 Quite High
dopamine receptor 8 8.64 Low Low
opiate 8 6.00 Low Low
withdrawal 8 5.44 Low Low
long-term potentiation 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Peripheral Neuropathy 12 98.12 Very High Very High Very High
Neuropathic Pain 4 95.64 Very High Very High Very High
Charcot Marie Tooth Disease 8 95.16 Very High Very High Very High
Disease 4 94.08 High High
Syndrome 4 92.96 High High
Apnoea 34 91.80 High High
Shock 80 89.60 High High
Repression 8 72.96 Quite High
Congenital Anomalies 18 59.16 Quite High
Cognitive Disorder 80 46.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All blots were probed for regulation of Egr1, Egr2, Egr3 and Actin; antibodies were stripped for the blot with Reblot (Chemicon Intentional) and three replicates per sample were made.
Regulation (regulation) of Egr2
1) Confidence 0.62 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.16 Pain Relevance 0
Consistent with this, Egr2 was shown to positively regulate the expression of Nab1 and Nab2 in the developing hindbrain (Mechta-Grigoriou et al., 2000, Desmazières, Charnay and Gilardi-Hebenstreit, unpublished data), and a gene expression profiling study in Schwann cells has identified Nab2 as a target of Egr2 (Nagarajan et al., 2001).
Regulation (target) of Egr2 in Schwann cells
2) Confidence 0.27 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.14 Pain Relevance 0
This suggests that in the absence of Egr2 there is neither compensatory regulation nor a linked detrimental effect on expression of Egr1 and Egr3.
Neg (neither) Regulation (regulation) of Egr2
3) Confidence 0.27 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.37 Pain Relevance 0.04
In humans, mutations affecting Egr2 are found in patients diagnosed for inherited peripheral neuropathies, including congenital hypomyelinating neuropathy, Charcot–Marie-Tooth type 1 disease and Dejerine–Sottas syndrome (Bellone et al., 1999; Boerkoel et al., 2001; Pareyson et al., 2000; Timmerman et al., 1999; Warner et al., 1998; Yoshihara et al., 2001).
Regulation (affecting) of Egr2 in Tooth associated with charcot marie tooth disease, syndrome, neuropathic pain, peripheral neuropathy and disease
4) Confidence 0.27 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.57 Pain Relevance 0.20
In r3, Hoxa2 function downstream of Krox20 may be partially redundant with that of its paralogue Hoxb2 [11], also a direct target of Krox20 [3].
Regulation (target) of Krox20
5) Confidence 0.26 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.15 Pain Relevance 0.05
In contrast, inactivation of either Hoxa2 or Krox20 impairs the rhythmic control of jaw opening, consistent with Hoxa2 being required for normal development of the trigeminal function [13] and Krox20 being a direct regulator of Hoxa2 in r3 [4,5].


Regulation (regulator) of Krox20 in jaw
6) Confidence 0.26 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0 Pain Relevance 0

General Comments

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