INT217100

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.44
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr2) intracellular (Egr2) DNA binding (Egr2)
ligase activity (Egr2) cytoplasm (Egr2)
Anatomy Link Frequency
respiratory 2
Egr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 2 95.36 Very High Very High Very High
fifth nerve 4 51.32 Quite High
narcan 14 5.00 Very Low Very Low Very Low
medulla 8 5.00 Very Low Very Low Very Low
Locus ceruleus 6 5.00 Very Low Very Low Very Low
parabrachial 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apnoea 34 99.68 Very High Very High Very High
Death 4 84.76 Quite High
Neurodegenerative Disease 6 24.00 Low Low
Targeted Disruption 14 15.60 Low Low
Congenital Anomalies 10 14.52 Low Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Birth Weight 4 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elimination of Krox20 expression in r3 reduces quiet breathing frequency by 50% and multiplies by 10 the time spent in apnea, eventually leading to opioid-sensitive lethality [17,26].
Negative_regulation (Elimination) of Gene_expression (expression) of Krox20 associated with apnoea and opioid
1) Confidence 0.57 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.36 Pain Relevance 0.12
Partial impairment of Krox20 function does not mimic the Hoxa2-/- respiratory phenotype and preserves breathing rhythm at birth
Negative_regulation (impairment) of Gene_expression (function) of Krox20 in respiratory
2) Confidence 0.42 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.07 Pain Relevance 0

General Comments

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