INT217102

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Context Info
Confidence 0.78
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 50
Total Number 50
Disease Relevance 10.91
Pain Relevance 3.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr2) intracellular (Egr2) DNA binding (Egr2)
ligase activity (Egr2) cytoplasm (Egr2)
Anatomy Link Frequency
hindbrain 5
embryos 4
brain 3
cortex 3
respiratory 3
Egr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 245 99.68 Very High Very High Very High
Pyramidal cell 24 99.60 Very High Very High Very High
amygdala 50 98.92 Very High Very High Very High
Central nervous system 54 98.68 Very High Very High Very High
dorsal root ganglion 31 97.24 Very High Very High Very High
Enkephalin 1 96.88 Very High Very High Very High
Somatostatin 1 96.04 Very High Very High Very High
Opioid 19 95.36 Very High Very High Very High
long-term potentiation 192 95.20 Very High Very High Very High
medulla 112 92.80 High High
Disease Link Frequency Relevance Heat
Cognitive Disorder 480 100.00 Very High Very High Very High
Apnoea 323 99.96 Very High Very High Very High
Peripheral Neuropathy 72 99.64 Very High Very High Very High
Targeted Disruption 382 99.48 Very High Very High Very High
Anxiety Disorder 492 98.84 Very High Very High Very High
Neurodegenerative Disease 59 97.72 Very High Very High Very High
Ganglion Cysts 47 97.24 Very High Very High Very High
Congenital Anomalies 175 94.40 High High
Syndrome 24 93.60 High High
Death 49 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To our knowledge, the only available study in which the expression of Egr2 was examined after behavioural learning showed no evidence for a regulated expression of Egr2 in structures such as the amygdala, hippocampus or cortex that could be attributed to learning in a single-trial contextual fear conditioning paradigm (Malkani and Rosen, 2000).
Gene_expression (expression) of Egr2 in cortex associated with anxiety disorder, hippocampus and amygdala
1) Confidence 0.78 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.47 Pain Relevance 0.33
In Schwann cells, for example, Egr1 and Egr2 are expressed in a successive and mutually exclusive manner during embryogenesis and examination of their role in myelination has suggested that they might compete and possibly repress each other (Topilko et al., 1997).
Gene_expression (expressed) of Egr2 in Schwann cells
2) Confidence 0.78 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.19 Pain Relevance 0
Generation of Egr2 conditional knock-out mice and genotyping
Gene_expression (Generation) of Egr2 associated with targeted disruption
3) Confidence 0.78 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.24 Pain Relevance 0
In the hippocampus, both Egr1 and Egr2 are highly expressed in CA1-3 pyramidal cells, with negligible basal levels in granule cells of the dentate gyrus (Herdegen et al., 1993; Mack et al., 1990; Yamagata et al., 1994).
Gene_expression (expressed) of Egr2 in pyramidal cells associated with pyramidal cell and hippocampus
4) Confidence 0.78 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.21 Pain Relevance 0.26
Egr2 expression is restricted to neurons in the central nervous system, with only glial cells of the peripheral system containing Egr2 (Herdegen et al., 1993).
Gene_expression (expression) of Egr2 in central nervous system associated with central nervous system
5) Confidence 0.78 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0.26
To our knowledge, the only available study in which the expression of Egr2 was examined after behavioural learning showed no evidence for a regulated expression of Egr2 in structures such as the amygdala, hippocampus or cortex that could be attributed to learning in a single-trial contextual fear conditioning paradigm (Malkani and Rosen, 2000).
Gene_expression (expression) of Egr2 in cortex associated with anxiety disorder, hippocampus and amygdala
6) Confidence 0.78 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.32 Pain Relevance 0.32
In cortex however, constitutive levels of Egr2 are highest in layers II and III but sparse in layers IV and VI, whereas Erg3 and Egr4 are highly expressed in layers II and IV (Beckmann and Wilce, 1997).
Gene_expression (levels) of Egr2 in cortex
7) Confidence 0.78 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.41 Pain Relevance 0.23
Thus, it is possible that Egr2, which seems expressed at lower levels than Egr1 and Egr3 in most brain regions as confirmed here in the dentate gyrus and area CA1 of the hippocampus, is not, or is less responsive to physiological neuronal activity during learning and is therefore dispensable for learning and memory.
Gene_expression (expressed) of Egr2 in neuronal associated with hippocampus
8) Confidence 0.78 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.32 Pain Relevance 0.23
Compound heterozygous Krox20Cre/flox mutants express Krox20 only transiently and, in the hindbrain, this results in a severe reduction of r3 (Figure 4).
Gene_expression (express) of Krox20 in hindbrain
9) Confidence 0.76 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.17 Pain Relevance 0
Krox20 expression in r3 was found necessary for the non-cell autonomous induction of a neuronal rhythm controller from r4 [27].
Gene_expression (expression) of Krox20 in neuronal
10) Confidence 0.76 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.37 Pain Relevance 0.08
The compound heterozygous animals, Krox20Cre/flox, express Krox20 only transiently, due to subsequent elimination of the second exon.
Gene_expression (express) of Krox20
11) Confidence 0.76 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.12 Pain Relevance 0
Alternatively, the present study also considers that abnormal inspiratory control in vivo may result from behavioral adaptation to r3-r5 defects in which Krox20 expression is altered but not entirely eliminated.
Gene_expression (expression) of Krox20
12) Confidence 0.76 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0 Pain Relevance 0.03
Because, in contrast, hypomorphic Krox20 neonates breathe at a normal rate without apneas, Krox20 expression must be entirely eliminated to alter respiration.
Gene_expression (expression) of Krox20 associated with apnoea
13) Confidence 0.76 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.36 Pain Relevance 0.10
Our results, therefore, suggest that the transient expression of Krox20 and the subsequent reduction of r3 size observed in hypomorphic Krox20 mutants do not prevent the development of the para-facial anti-apneic system.
Gene_expression (expression) of Krox20
14) Confidence 0.76 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.39 Pain Relevance 0.09
Functional redundancy of Hox2 paralogs can be expected at early developmental stages (end-segmental stages, about E9.5), during which Krox20 expression initiates formation of rhythm generators.
Gene_expression (expression) of Krox20 in developmental stages
15) Confidence 0.76 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.14 Pain Relevance 0.04
To further explore the parafacial development in mouse embryos, experiments are in progress in our laboratories to identify cell lineages that could be targets of the induction initiated by Krox20 expression.


Gene_expression (expression) of Krox20 in embryos
16) Confidence 0.76 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.20 Pain Relevance 0.03
Furthermore, ectopic Krox20-expression in a limited territory (for example, obtained by unilateral electroporation in a rhombomere) was sufficient to induce a fully functional rhythm generator, although the population of neurons specified by Krox20 was certainly smaller than normal r3 in these preparations [27].
Gene_expression (expression) of Krox20 in neurons
17) Confidence 0.76 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.29 Pain Relevance 0.06
Elimination of Krox20 expression in r3 reduces quiet breathing frequency by 50% and multiplies by 10 the time spent in apnea, eventually leading to opioid-sensitive lethality [17,26].
Gene_expression (expression) of Krox20 associated with apnoea and opioid
18) Confidence 0.76 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.36 Pain Relevance 0.12
The consequences of Egr2 inactivation were explored in conventional Egr2-null mutant mice and these studies revealed a prominent role of Egr2 in the regulation of peripheral nerve myelination (Topilko et al., 1994) as well as in hindbrain segmentation (Giudicelli et al., 2001; Schneider-Maunoury et al., 1993; Swiatek and Gridley, 1993) and endochondreal bone formation (Levi et al., 1996).
Gene_expression (explored) of Egr2 in peripheral nerve
19) Confidence 0.67 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.60 Pain Relevance 0.09
The consequences of Egr2 inactivation were explored in conventional Egr2-null mutant mice and these studies revealed a prominent role of Egr2 in the regulation of peripheral nerve myelination (Topilko et al., 1994) as well as in hindbrain segmentation (Giudicelli et al., 2001; Schneider-Maunoury et al., 1993; Swiatek and Gridley, 1993) and endochondreal bone formation (Levi et al., 1996).
Gene_expression (explored) of Egr2 in peripheral nerve
20) Confidence 0.67 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.60 Pain Relevance 0.09

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