INT217105

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.21
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hoxa2) DNA binding (Hoxa2)
Anatomy Link Frequency
respiratory 3
jaw 1
Hoxa2 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 35 53.84 Quite High
medulla 20 5.00 Very Low Very Low Very Low
Locus ceruleus 15 5.00 Very Low Very Low Very Low
parabrachial 15 5.00 Very Low Very Low Very Low
fifth nerve 10 5.00 Very Low Very Low Very Low
Opioid 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apnoea 85 81.12 Quite High
Targeted Disruption 35 78.00 Quite High
Congenital Anomalies 25 19.04 Low Low
Body Weight 5 11.52 Low Low
Neurodegenerative Disease 15 5.00 Very Low Very Low Very Low
Sprains And Strains 10 5.00 Very Low Very Low Very Low
Birth Weight 10 5.00 Very Low Very Low Very Low
Death 10 5.00 Very Low Very Low Very Low
Hyperplasia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The abnormal inspiratory control in Hoxa2 mutants might, therefore, originate from an adaptive respiratory behavior following compensation for the loss of Hoxa2 in r3, while Krox20 is still functional.
Negative_regulation (loss) of Hoxa2 in respiratory
1) Confidence 0.58 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.08 Pain Relevance 0
We found that inactivation of either Hoxa2 or Krox20 impairs the rhythmic control of the jaw opening in agreement with HOXA2-dependent trigeminal defects and direct regulation of Hoxa2 by KROX20 in r3.
Negative_regulation (inactivation) of Hoxa2 in jaw
2) Confidence 0.43 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0 Pain Relevance 0
The changes of VT during the first hours were, therefore, mostly responsible for the modifications of the VE and both were abolished in Hoxa2-/- mutant mice.
Negative_regulation (abolished) of Hoxa2
3) Confidence 0.42 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.08 Pain Relevance 0
Hoxa2 inactivation, affecting the r1-r2 region and respiratory amplitude, did not severely perturb respiratory rhythm that requires normal Krox20 and Hoxa1 expression in the r3-r5 region [26].
Negative_regulation (inactivation) of Hoxa2 in respiratory
4) Confidence 0.37 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0.05 Pain Relevance 0.03
In contrast, while Krox20 is required for the development of the rhythm-promoting parafacial respiratory group (pFRG) modulating respiratory frequency, Hoxa2 inactivation did not affect neonatal breathing frequency.
Negative_regulation (inactivation) of Hoxa2 in respiratory
5) Confidence 0.37 Published 2007 Journal Neural Develop Section Abstract Doc Link PMC2098766 Disease Relevance 0 Pain Relevance 0

General Comments

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