INT217150

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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.89
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)
MIR16-2 (Homo sapiens)
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 34 100.00 Very High Very High Very High
Cancer 174 98.20 Very High Very High Very High
Chronic Lymphoid Leukemia 15 93.44 High High
Neuroblastoma 6 87.32 High High
Genetic Translocation 3 66.48 Quite High
Lung Cancer 18 62.56 Quite High
Repression 4 60.96 Quite High
Colon Cancer 9 51.24 Quite High
Adenocarcinoma 8 12.64 Low Low
Carcinoma 4 12.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, miR-15 and miR-16 induce apoptosis by targeting Bcl2. miRNAs from the miR-17-92 cluster modulate tumor formation and function as oncogenes by influencing the translation of E2F1 mRNA. miR-21 modulates gemcitabine-induced apoptosis by phosphatase and tensin homolog deleted on chromosome 10-dependent activation of PI 3-kinase signaling. miR-34a acts as a suppressor of neuroblastoma tumorigenesis by targeting the mRNA encoding E2F3 and reducing E2F3 protein levels.
miR-16 Regulation (targeting) of Bcl2 associated with neuroblastoma, cancer and apoptosis
1) Confidence 0.09 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC2098778 Disease Relevance 0.85 Pain Relevance 0
Finally, they identified the biological effects of down regulating bcl-2 by miR-15 and miR-16.
miR-16 Regulation (regulating) of bcl-2
2) Confidence 0.00 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 1.04 Pain Relevance 0

General Comments

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