INT217156

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 16.04
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 2
colon 2
MIR21 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 4 99.92 Very High Very High Very High
Pain 5 86.36 High High
Bile 4 83.04 Quite High
Chronic pancreatitis 19 70.56 Quite High
addiction 8 69.48 Quite High
agonist 43 50.00 Quite Low
Central nervous system 5 7.56 Low Low
Inflammation 24 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 33 99.88 Very High Very High Very High
Pancreatic Cancer 93 99.84 Very High Very High Very High
Chronic Lymphoid Leukemia 80 99.84 Very High Very High Very High
Breast Cancer 63 99.84 Very High Very High Very High
Glioblastoma 42 99.84 Very High Very High Very High
Malignant Neoplastic Disease 38 99.84 Very High Very High Very High
Colon Cancer 53 99.60 Very High Very High Very High
Multiple Myeloma 57 99.56 Very High Very High Very High
Cancer 1395 99.16 Very High Very High Very High
Prostate Cancer 100 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using miRNA cloning and qRT-PCR of mature miRNAs, Fulci et al. demonstrated that miR-21 and miR-155 were dramatically overexpressed in CLL patients [24].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of miR-21 associated with chronic lymphoid leukemia
1) Confidence 0.49 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 0.92 Pain Relevance 0
Meng et al. identified miR-21 was also highly overexpressed in malignant cholangiocytes.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of miR-21 associated with malignant neoplastic disease
2) Confidence 0.43 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.14 Pain Relevance 0
Si et al. found that miR-21 was highly overexpressed in breast tumors compared to the matched normal breast tissues.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of miR-21 associated with breast cancer
3) Confidence 0.43 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 0.94 Pain Relevance 0.03
Roldo et al. showed that the overexpression of miR-21 in pancreatic tumors was strongly associated with both high Ki67 proliferation index and the presence of liver metastasis.
Positive_regulation (overexpression) of Gene_expression (overexpression) of miR-21 in liver associated with pancreatic cancer and metastasis
4) Confidence 0.29 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.30 Pain Relevance 0.13
MiR-21 is overexpressed in glioblastoma tissues and cells and acts as an antiapoptotic factor in cultured glioblastoma cells [57].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of MiR-21 associated with glioblastoma
5) Confidence 0.22 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 2.47 Pain Relevance 0.05
MiR-21 is overexpressed in various types of cancer indicating that miR-21 is involved in tumor growth, invasion and metastasis.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of MiR-21 associated with cancer and metastasis
6) Confidence 0.19 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.91 Pain Relevance 0.09
From the results miR-21 was found to be strongly overexpressed in the neoplastic samples.


Positive_regulation (overexpressed) of Gene_expression (overexpressed) of miR-21
7) Confidence 0.19 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 2.61 Pain Relevance 0.04
As that of miR-21, miR-17-5p is overexpressed (shown with solid lines in Figure 1) in their associated tumor types, showing strong oncogenic characteristics.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of miR-21 associated with cancer
8) Confidence 0.16 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.12 Pain Relevance 0.04
A similar explanation was previously documented by Rossi et al. to explain the increase in miR-21 expression in human colon cancer cells after exposure to 5-fluorouracil in vitro [84]. miR-21 has been shown to have proliferative, metastatic, and anti-apoptotic functions in cancer by targeting genes such as PTEN, TPM1, Pdcd4, and maspin.
Positive_regulation (increase) of Gene_expression (expression) of miR-21 in colon associated with cancer, colon cancer and apoptosis
9) Confidence 0.08 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.69 Pain Relevance 0
For example, we found an increased expression of the oncogenic miR-21 in B-DIM treated Colo-357 which was unexpected, whereas most of the results displayed decreased expression of oncogenic miRNAs and increased expression of tumor suppressor miRNAs upon treatment with either agent, clearly supporting the role of B-DIM or G2535 as cancer preventing agents.
Positive_regulation (increased) of Gene_expression (expression) of miR-21 associated with cancer
10) Confidence 0.08 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.36 Pain Relevance 0
Si et al. found increased expression of miR-21 to be present in breast tumor tissues as well [61].
Positive_regulation (increased) of Gene_expression (expression) of miR-21 associated with breast cancer
11) Confidence 0.08 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 1.07 Pain Relevance 0
Overexpression of miR-21 occurs in MM [246, 257] and other cancers including glioblastoma [258] and breast cancer [259].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of miR-21 associated with glioblastoma, cancer, breast cancer and multiple myeloma
12) Confidence 0.08 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.52 Pain Relevance 0

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