INT217166

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 7.09
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lung 4
MIR17HG (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 6 98.40 Very High Very High Very High
Inflammatory response 2 92.88 High High
rheumatoid arthritis 1 90.32 High High
psoriasis 1 84.40 Quite High
Inflammation 20 80.16 Quite High
corticosteroid 20 50.00 Quite Low
agonist 2 19.12 Low Low
Chronic pancreatitis 10 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 64 99.86 Very High Very High Very High
Apoptosis 93 99.32 Very High Very High Very High
Solid Tumor 1 98.80 Very High Very High Very High
Cancer 452 98.68 Very High Very High Very High
Targeted Disruption 6 97.88 Very High Very High Very High
Lymphatic System Cancer 24 96.76 Very High Very High Very High
Malignant Neoplastic Disease 22 96.12 Very High Very High Very High
INFLAMMATION 23 92.52 High High
Rheumatoid Arthritis 1 90.32 High High
Repression 16 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, overexpression of the miR-17-92 cluster is thought to influence tumour progression [18], and is controlled by the transcription factor c-myc [19].
Gene_expression (overexpression) of miR-17-92 associated with cancer
1) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690402 Disease Relevance 1.48 Pain Relevance 0.17
After inducing expression of the miR-17-92 cluster, they noticed that animals expressing both c-myc and the miRNA cluster developed highly malignant, disseminated lymphomas capable of evading apoptosis [50].
Gene_expression (expression) of miR-17-92 associated with malignant neoplastic disease, lymphatic system cancer and apoptosis
2) Confidence 0.47 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 1.09 Pain Relevance 0
Falling into this category is the group of six miRNAs termed the miR-17-92 cluster which is made up of miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1, and miR-92-1 [49].
Gene_expression (made) of miR-17-92
3) Confidence 0.36 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.86 Pain Relevance 0
Their findings suggested that marked overexpression of the miR-17-92 cluster with occasional gene amplification might play a role in the development of lung cancer and that the C13orf25 gene might well be serving as a vehicle in this regard [16].
Gene_expression (overexpression) of miR-17-92 in lung associated with lung cancer
4) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 0.84 Pain Relevance 0.03
Matsubara et al. showed that inhibition of miR-17-5p and miR-20a with antisense oligonucleotides could induce apoptosis selectively in lung cancer cells overexpressing miR-17-92, suggesting the possibility of oncomiR addiction to expression of these miRNAs in a subset of lung cancers.
Gene_expression (overexpressing) of miR-17-92 in lung associated with addiction, lung cancer and apoptosis
5) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 0.76 Pain Relevance 0.05
On the other hand, Hayashita et al. found that miR-17-92 was markedly overexpressed in lung cancer, especially with small-cell lung cancer.
Gene_expression (overexpressed) of miR-17-92 in lung associated with lung cancer
6) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 0.93 Pain Relevance 0.03
Amplification and overexpression of the miR-17-92, which comprised 7 miRNAs and resided in intron 3 of the C13orf25 gene at 13q31.3, has been reported with pointers to functional involvement in the development of lymphoma and lung cancer.
Gene_expression (overexpression) of miR-17-92 in lung associated with lung cancer and lymphatic system cancer
7) Confidence 0.23 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.13 Pain Relevance 0

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