INT217168

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 30.86
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lymph node 2
cerebrum 1
liver 1
colon 1
neck 1
MIR21 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 11 99.92 Very High Very High Very High
Bile 7 98.80 Very High Very High Very High
Pain 9 88.56 High High
Chronic pancreatitis 34 70.56 Quite High
addiction 17 69.48 Quite High
Bioavailability 2 51.68 Quite High
agonist 88 50.00 Quite Low
cytokine 37 45.60 Quite Low
metalloproteinase 10 28.88 Quite Low
Central nervous system 38 23.32 Low Low
Disease Link Frequency Relevance Heat
Prostate Cancer 192 100.00 Very High Very High Very High
Carcinoma 69 99.88 Very High Very High Very High
Pancreatic Cancer 164 99.84 Very High Very High Very High
Chronic Lymphoid Leukemia 161 99.84 Very High Very High Very High
Breast Cancer 116 99.84 Very High Very High Very High
Colon Cancer 100 99.84 Very High Very High Very High
Malignant Neoplastic Disease 83 99.84 Very High Very High Very High
Glioblastoma 79 99.84 Very High Very High Very High
Multiple Myeloma 127 99.56 Very High Very High Very High
Head & Neck Cancer 6 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using miRNA cloning and qRT-PCR of mature miRNAs, Fulci et al. demonstrated that miR-21 and miR-155 were dramatically overexpressed in CLL patients [24].
Gene_expression (overexpressed) of miR-21 associated with chronic lymphoid leukemia
1) Confidence 0.55 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 0.92 Pain Relevance 0
Meng et al. identified miR-21 was also highly overexpressed in malignant cholangiocytes.
Gene_expression (overexpressed) of miR-21 associated with malignant neoplastic disease
2) Confidence 0.48 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.14 Pain Relevance 0
Si et al. found that miR-21 was highly overexpressed in breast tumors compared to the matched normal breast tissues.
Gene_expression (overexpressed) of miR-21 associated with breast cancer
3) Confidence 0.48 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 0.94 Pain Relevance 0.03
Tran et al. found that miR-21 was highly expressed in the head and neck cancer cell lines.
Gene_expression (expressed) of miR-21 in head associated with head & neck cancer
4) Confidence 0.48 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.18 Pain Relevance 0
Roldo et al. showed that the overexpression of miR-21 in pancreatic tumors was strongly associated with both high Ki67 proliferation index and the presence of liver metastasis.
Gene_expression (overexpression) of miR-21 in liver associated with pancreatic cancer and metastasis
5) Confidence 0.37 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.30 Pain Relevance 0.13
Expression profiles for additional tissues (testis, femoral and coronary arteries, omental fat and cerebrum) showed expression of miR21, 26b, 30a-5p and 760, and tissue specific expression of miR16-1. miRNAs that did not show a detectable signal on the miRNA array did not show a product using RT-PCR validating the specificity of the miRNA array data for both the expressed and undetected miRNAs.


Gene_expression (expression) of miR21 in cerebrum
6) Confidence 0.26 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2905361 Disease Relevance 0 Pain Relevance 0
We confirmed expression of miR21, 26b, 30a-5p, 760, and 16-1 (Figure 2) and lack of detectable expression for miR302a, 648, and 373.
Gene_expression (expression) of miR21
7) Confidence 0.26 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2905361 Disease Relevance 0 Pain Relevance 0
MiR-21 is overexpressed in glioblastoma tissues and cells and acts as an antiapoptotic factor in cultured glioblastoma cells [57].
Gene_expression (overexpressed) of MiR-21 associated with glioblastoma
8) Confidence 0.25 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 2.47 Pain Relevance 0.05
MiR-21 is overexpressed in various types of cancer indicating that miR-21 is involved in tumor growth, invasion and metastasis.
Gene_expression (overexpressed) of MiR-21 associated with cancer and metastasis
9) Confidence 0.21 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.91 Pain Relevance 0.09
Differential expression of miR-21 in these 10 specimens was verified by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR).
Gene_expression (expression) of miR-21
10) Confidence 0.21 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.17 Pain Relevance 0.05
From the results miR-21 was found to be strongly overexpressed in the neoplastic samples.


Gene_expression (overexpressed) of miR-21
11) Confidence 0.21 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 2.61 Pain Relevance 0.04
As that of miR-21, miR-17-5p is overexpressed (shown with solid lines in Figure 1) in their associated tumor types, showing strong oncogenic characteristics.
Gene_expression (overexpressed) of miR-21 associated with cancer
12) Confidence 0.21 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.12 Pain Relevance 0.04
Patients with high expression of either miR-155, miR-17-3p, miR-106a, miR-93 or miR-21 and low expression of either let-7a-2, let-7b or miR-145 were found to have a significantly worse prognosis.
Gene_expression (expression) of miR-21
13) Confidence 0.19 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.97 Pain Relevance 0
In [21], expression profiling revealed that a number of miRNAs are differentially expressed in prostate cancer tissues including miR-21.
Gene_expression (expressed) of miR-21 associated with prostate cancer
14) Confidence 0.19 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.85 Pain Relevance 0.09
Tran et al. found that miR-21 was highly expressed in the head and neck cancer cell lines.
Gene_expression (expressed) of miR-21 in neck associated with head & neck cancer
15) Confidence 0.16 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.18 Pain Relevance 0
Amaral et al. [12] found that the expression of miR-21, miR-141 and miR-150 was reduced in corticotropinomas.
Gene_expression (expression) of miR-21
16) Confidence 0.10 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.97 Pain Relevance 0
However, in this study, we did not observe significant difference of miR-21 and miR-141 expression between micro- and macro-GH-secreting pituitary adenomas.
Gene_expression (expression) of miR-21 in pituitary associated with pituitary cancer
17) Confidence 0.10 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.88 Pain Relevance 0.03
For example, we found an increased expression of the oncogenic miR-21 in B-DIM treated Colo-357 which was unexpected, whereas most of the results displayed decreased expression of oncogenic miRNAs and increased expression of tumor suppressor miRNAs upon treatment with either agent, clearly supporting the role of B-DIM or G2535 as cancer preventing agents.
Gene_expression (expression) of miR-21 associated with cancer
18) Confidence 0.09 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.36 Pain Relevance 0
Si et al. found increased expression of miR-21 to be present in breast tumor tissues as well [61].
Gene_expression (expression) of miR-21 associated with breast cancer
19) Confidence 0.09 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 1.06 Pain Relevance 0
A similar explanation was previously documented by Rossi et al. to explain the increase in miR-21 expression in human colon cancer cells after exposure to 5-fluorouracil in vitro [84]. miR-21 has been shown to have proliferative, metastatic, and anti-apoptotic functions in cancer by targeting genes such as PTEN, TPM1, Pdcd4, and maspin.
Gene_expression (expression) of miR-21 in colon associated with cancer, colon cancer and apoptosis
20) Confidence 0.09 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.68 Pain Relevance 0

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