INT217170

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 10
Disease Relevance 8.17
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
pituitary 5
blood 1
MIR15A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 9 95.04 Very High Very High Very High
Somatostatin 28 5.00 Very Low Very Low Very Low
imagery 14 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Bioavailability 7 5.00 Very Low Very Low Very Low
tolerance 7 5.00 Very Low Very Low Very Low
headache 7 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
Chronic pancreatitis 4 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 295 100.00 Very High Very High Very High
Pituitary Cancer 279 99.88 Very High Very High Very High
Chronic Lymphoid Leukemia 20 98.04 Very High Very High Very High
Hematologic Neoplasms 9 89.84 High High
Repression 8 89.04 High High
Thyroid Neoplasm 13 88.64 High High
Recurrence 10 88.16 High High
Apoptosis 71 86.24 High High
Diffuse Large B-cell Lymphoma 56 62.72 Quite High
B-cell Lymphoma 27 58.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was no correlation between the reduced expression of miR-15a and tumor size (miR-15a, down-regulated, 0.32, P = 0.21, FDR = 0.076, A P value >0.05, the data wasn't shown in the Table 1).
Gene_expression (expression) of miR-15a associated with cancer
1) Confidence 0.75 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.75 Pain Relevance 0
Among 9 differentially expressed miRNAs between micro- and macro- GH-secreting pituitary adenomas, the expression of miR-15a was down-regulated.
Gene_expression (expression) of miR-15a in pituitary associated with pituitary cancer
2) Confidence 0.75 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.74 Pain Relevance 0
Further more, the expression level of miR-15a and miR-16-1 is inversely correlated with tumor diameter and directly correlated with the secretion of the anti-neoplastic cytokine p43 [10].
Gene_expression (expression) of miR-15a associated with cancer and cytokine
3) Confidence 0.75 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.78 Pain Relevance 0.05
Bottoni et al. [10] demonstrated an inverse correlation between the tumor diameter and the expression level of miR-15a and miR-16 in samples of GH- or PRL-secreting pituitary adenomas, which was different from our findings.
Gene_expression (expression) of miR-15a in pituitary associated with cancer and pituitary cancer
4) Confidence 0.75 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.83 Pain Relevance 0
Previous studies have shown that expression of miR-15a and miR-16-1 in pituitary adenomas is lower than that in the normal pituitary tissues.
Gene_expression (expression) of miR-15a in pituitary associated with pituitary cancer
5) Confidence 0.75 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.72 Pain Relevance 0.04
In short, these findings suggested a role of reduced expression of miR-15a and miR-16 in the pathogenesis of pituitary tumors.
Gene_expression (expression) of miR-15a in pituitary associated with pituitary cancer
6) Confidence 0.75 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.85 Pain Relevance 0
No correlation was found between miR-15a and miR-16 expression levels and 13q14 deletion in the blood CLL samples [37].
Gene_expression (expression) of miR-15a in blood
7) Confidence 0.75 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.31 Pain Relevance 0
There was no correlation between the reduced expression of miR-15a and tumor size (miR-15a, down-regulated, 0.32, P = 0.21, FDR = 0.076, A P value >0.05, the data wasn't shown in the Table 1).
Gene_expression (expression) of miR-15a associated with cancer
8) Confidence 0.58 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.76 Pain Relevance 0
Bottoni et al. found that miR-15a and miR-16-1 were expressed at lower levels in pituitary adenomas as compared to normal pituitary tissue.
Gene_expression (expressed) of miR-15a in pituitary associated with pituitary cancer
9) Confidence 0.28 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.24 Pain Relevance 0
Cimmino et al. then demonstrated that miR-15a and miR-16-1 expressions were inversely correlated to Bcl2 expression in CLL and that both miRNAs negatively regulated Bcl2 at a posttranscriptional level.
Gene_expression (expressions) of miR-15a associated with chronic lymphoid leukemia
10) Confidence 0.28 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.19 Pain Relevance 0

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