INT217173

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.37
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 1
MIR15B (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 3 84.48 Quite High
Inflammation 58 73.56 Quite High
agonist 86 50.00 Quite Low
Pain 3 47.28 Quite Low
cytokine 12 5.00 Very Low Very Low Very Low
ischemia 8 5.00 Very Low Very Low Very Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
dexamethasone 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Lymphoid Leukemia 22 99.84 Very High Very High Very High
Hematologic Neoplasms 79 99.42 Very High Very High Very High
Cancer 373 98.84 Very High Very High Very High
Breast Cancer 16 98.70 Very High Very High Very High
Death 15 93.56 High High
Apoptosis 74 92.96 High High
Pituitary Cancer 42 89.92 High High
Necrosis 3 89.20 High High
Malignant Neoplastic Disease 27 88.72 High High
Multiple Myeloma 106 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It should be noted that other microRNAs potentially regulating CCNE1 protein expression were also significantly changed, including down-regulation of miR-141, miR-16, miR-15a, miR-352, miR-15b and up-regulation of miR-518e, miR-29a, miR-192, and miR-29b, implicating a regulatory network fine-tuning the cell cycle checkpoints.
Negative_regulation (down-regulation) of miR-15b
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944884 Disease Relevance 0 Pain Relevance 0
Iorio et al. showed that miRNAs were aberrantly expressed in human breast cancer compared with normal breast tissue, with the most significantly downregulated miRNAs being miR-10b, miR-125b and miR-145, whereas the most significantly upregulated miRNAs being miR-21 and miR-155.
Negative_regulation (downregulated) of miR-125b associated with breast cancer
2) Confidence 0.11 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 0.90 Pain Relevance 0.04
We found that lipopolysaccharide (LPS) stimulation of mouse Raw 264.7 macrophages resulted in the upregulation of miR-155 and downregulation of miR-125b levels.
Negative_regulation (downregulation) of miR-125b in macrophages
3) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 1.03 Pain Relevance 0.04
For example, Calin and colleagues [248] first implicated miRNAs in hematological malignancies when they demonstrated that miR-15 and miR-16 are frequently deleted or downregulated in CLL associated with deletions on chromosome 13q14.
Negative_regulation (downregulated) of miR-15 associated with chronic lymphoid leukemia and hematologic neoplasms
4) Confidence 0.04 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.87 Pain Relevance 0
For example, Calin and colleagues [248] first implicated miRNAs in hematological malignancies when they demonstrated that miR-15 and miR-16 are frequently deleted or downregulated in CLL associated with deletions on chromosome 13q14.
Negative_regulation (downregulated) of miR-15 associated with chronic lymphoid leukemia and hematologic neoplasms
5) Confidence 0.03 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.87 Pain Relevance 0
Ferretti et al. [21] found that down-regulation of miR-125b caused the proliferation of tumor cells.
Negative_regulation (regulation) of miR-125b associated with cancer
6) Confidence 0.01 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.71 Pain Relevance 0

General Comments

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