INT217195

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.54
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (HMGA2) protein binding transcription factor activity (HMGA2) DNA binding (HMGA2)
mitosis (HMGA2) nucleus (HMGA2) nucleic acid binding transcription factor activity (HMGA2)
Anatomy Link Frequency
lung 1
HMGA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 6 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 12 100.00 Very High Very High Very High
Cancer 150 99.70 Very High Very High Very High
Genetic Translocation 9 99.10 Very High Very High Very High
Lung Cancer 39 98.92 Very High Very High Very High
Adenocarcinoma 9 90.80 High High
Neurofibromatosis 2 3 81.44 Quite High
Skin Cancer 3 76.00 Quite High
Malignant Neoplastic Disease 15 73.52 Quite High
Colon Cancer 18 67.16 Quite High
Hypoxia 3 52.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mayr et al. reported that the chromosomal translocations associating with human tumors disrupted the repression of High mobility group A2 (Hmga2) by let-7 miRNA.
Negative_regulation (repression) of High mobility group A2 associated with cancer, genetic translocation and repression
1) Confidence 0.55 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.17 Pain Relevance 0
Mayr et al. reported that the chromosomal translocations associating with human tumors disrupted the repression of High mobility group A2 (Hmga2) by let-7 miRNA.
Negative_regulation (repression) of Hmga2 associated with cancer, genetic translocation and repression
2) Confidence 0.55 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.22 Pain Relevance 0
Lee and Dutta also demonstrated that ectopic expression of let-7 miRNA reduced Hmga2 and cell proliferation in lung cancer cell.
Negative_regulation (reduced) of Hmga2 in lung associated with lung cancer
3) Confidence 0.40 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.15 Pain Relevance 0

General Comments

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