INT21720

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Context Info
Confidence 0.43
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.98
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
pancreas 2
Lpo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
emotional pain 3 93.96 High High
Pain 7 91.36 High High
Inflammation 9 81.84 Quite High
ischemia 9 72.36 Quite High
anesthesia 6 44.00 Quite Low
Bile 5 39.60 Quite Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Versed 4 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Thoracotomy 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 51 99.98 Very High Very High Very High
Pain 6 93.96 High High
Disorder Of Lipid Metabolism 25 89.36 High High
Peripheral Arterial Disease 8 88.20 High High
Coronary Artery Disease 7 85.44 High High
INFLAMMATION 9 81.84 Quite High
Asphyxia 14 80.72 Quite High
Body Weight 17 80.00 Quite High
Necrosis 3 79.60 Quite High
Atherosclerosis 5 75.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Carnosine given before stress prevents LPO activation.
Negative_regulation (prevents) of Positive_regulation (activation) of LPO associated with stress
1) Confidence 0.43 Published 1989 Journal Biull Eksp Biol Med Section Abstract Doc Link 2923966 Disease Relevance 0.44 Pain Relevance 0.09
Pretreatment with GHBA or ionol completely reverses LPO activation.
Negative_regulation (reverses) of Positive_regulation (activation) of LPO
2) Confidence 0.43 Published 1980 Journal Biull Eksp Biol Med Section Abstract Doc Link 7470598 Disease Relevance 0.43 Pain Relevance 0.25
Concomitant treatment of rats with sulphated polysaccharides significantly (P < 0.001) reduced the elevated levels of LPO, 8-OHdG and protein carbonyl close to that of controls, thereby strongly confirming its potential in inhibiting the oxidation of macromolecules like lipids, DNA and proteins.


Negative_regulation (reduced) of Positive_regulation (elevated) of LPO
3) Confidence 0.41 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2291455 Disease Relevance 0.09 Pain Relevance 0
Antioxidant administration prevents LPO process activation in the pancreas and inhibits, to a great extent, a decrease in the level of insulin in stress.
Negative_regulation (prevents) of Positive_regulation (activation) of LPO in pancreas associated with stress
4) Confidence 0.35 Published 1990 Journal Probl Endokrinol (Mosk) Section Abstract Doc Link 2194205 Disease Relevance 0.51 Pain Relevance 0.16
Pretreatment with methanol extract of CQ significantly prevented the increase in LPO (P < 0.001) and decrease in GSH (P < 0.05), SOD (P < 0.05), and CAT (P < 0.001).
Negative_regulation (prevented) of Positive_regulation (increase) of LPO
5) Confidence 0.29 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2991701 Disease Relevance 0.38 Pain Relevance 0.08
Feeding with HFD produced an increased LPO in the group II animals (P<0.001), which was significantly reduced by the treatment with MEEV (200 and 400 mg/kg) in group III and IV animals, respectively [Table 2].
Negative_regulation (reduced) of Positive_regulation (increased) of LPO
6) Confidence 0.14 Published 2010 Journal Journal of Pharmacy and Bioallied Sciences Section Body Doc Link PMC2996074 Disease Relevance 0.63 Pain Relevance 0
Injection of natural and synthetic free radical scavengers (e. g. 4-methyl-2.6-ditretbutylphenol, alpha-tocopherol) to experimental animals resulted in practically complete suppression of LPO activation "in vivo" and in partial protection of the Ca2+-transporting capacity of SR membranes.
Negative_regulation (suppression) of Positive_regulation (activation) of LPO
7) Confidence 0.09 Published 1983 Journal Biokhimiia Section Abstract Doc Link 6225470 Disease Relevance 0.22 Pain Relevance 0.11
NAC treatments also attenuated myocardial LPO accumulation, caspase-3 activity as well as lactate content, and reduced the plasma cTnI concentration by the end of reoxygenation period.
Negative_regulation (attenuated) of Positive_regulation (accumulation) of LPO in plasma
8) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3006425 Disease Relevance 0.20 Pain Relevance 0
R control piglets was significantly higher than those of sham-operated piglets, and the LPO accumulation was significantly reduced by NAC treatment (Table 2).
Negative_regulation (reduced) of Positive_regulation (accumulation) of LPO
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3006425 Disease Relevance 0.08 Pain Relevance 0

General Comments

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