INT21721

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Context Info
Confidence 0.60
First Reported 1990
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 16.33
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
stomach 4
hepatocytes 3
duodenum 2
liver 1
spinal cord 1
Lpo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 3 99.60 Very High Very High Very High
Sciatic nerve 4 99.36 Very High Very High Very High
Angina 5 98.76 Very High Very High Very High
ischemia 6 98.72 Very High Very High Very High
emotional pain 1 98.62 Very High Very High Very High
Eae 3 98.12 Very High Very High Very High
Thermal hyperalgesia 6 93.04 High High
Hyperalgesia 1 92.32 High High
Paracetamol 90 85.92 High High
Somatostatin 196 80.08 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 529 99.86 Very High Very High Very High
Death 6 98.96 Very High Very High Very High
Hepatotoxicity 113 98.88 Very High Very High Very High
Gallstones 7 98.80 Very High Very High Very High
Stress 130 98.76 Very High Very High Very High
Cv General 3 Under Development 5 98.76 Very High Very High Very High
Pain 5 98.62 Very High Very High Very High
Urological Neuroanatomy 34 98.56 Very High Very High Very High
Hyperlipidemia 23 98.52 Very High Very High Very High
Disease 11 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding evidenced that concentration of LPO products in the sera of patients with gallstone disease may be of great significance for diagnosis of associated pancreatitis and early predictor of outcome.
Gene_expression (products) of LPO associated with pancreatitis, disease and gallstones
1) Confidence 0.60 Published 1998 Journal Vopr. Med. Khim. Section Abstract Doc Link 10599144 Disease Relevance 1.10 Pain Relevance 0.07
In the diabetic rats, an increase in stomach LPO levels was observed.
Gene_expression (levels) of LPO in stomach associated with diabetes mellitus
2) Confidence 0.54 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831851 Disease Relevance 0.53 Pain Relevance 0.07
In the diabetic rats, LPO levels were significantly different between groups (PANOVA=0.0001).
Gene_expression (levels) of LPO associated with diabetes mellitus
3) Confidence 0.54 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831851 Disease Relevance 1.21 Pain Relevance 0
These results suggest that SNT was not a strong enough stimulus to deplete all antioxidant content in the spinal cord, since increase in LPO was not detected.
Neg (not) Gene_expression (detected) of LPO in spinal cord associated with spinal cord
4) Confidence 0.51 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16770731 Disease Relevance 0.46 Pain Relevance 0.41
The development of emotional pain stress in rats is accompanied by an increase in lipid peroxidation (LPO) products in the pancreas and a decrease in antiradical activity of its lipids.
Gene_expression (products) of LPO in pancreas associated with stress, pain and emotional pain
5) Confidence 0.49 Published 1990 Journal Probl Endokrinol (Mosk) Section Abstract Doc Link 2194205 Disease Relevance 0.49 Pain Relevance 0.17
The concentration of LPO is expressed as the amount of malondialdehyde (MDA) equivalents.
Gene_expression (expressed) of LPO
6) Confidence 0.48 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266062 Disease Relevance 0 Pain Relevance 0
In diabetic rats treated with zinc sulfate, the duodenum LPO levels decreased significantly when compared with the diabetic group (bp<0.0001).
Gene_expression (levels) of LPO in duodenum associated with diabetes mellitus
7) Confidence 0.47 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831851 Disease Relevance 1.32 Pain Relevance 0
Administration of zinc sulfate was found to reduce stomach LPO levels in diabetic rats, but in the nondiabetic control groups, it significantly increased the stomach LPO levels (ap<0.0001).
Gene_expression (levels) of LPO in stomach associated with diabetes mellitus
8) Confidence 0.47 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831851 Disease Relevance 0.62 Pain Relevance 0.07
In the diabetic rats, stomach and duodenum LPO levels were significantly higher than those of the other groups.
Gene_expression (levels) of LPO in stomach associated with diabetes mellitus
9) Confidence 0.47 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831851 Disease Relevance 1.49 Pain Relevance 0.12
Administration of zinc sulfate was found to reduce stomach LPO levels in diabetic rats, but in the nondiabetic control groups, it significantly increased the stomach LPO levels (ap<0.0001).
Gene_expression (levels) of LPO in stomach associated with diabetes mellitus
10) Confidence 0.47 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831851 Disease Relevance 0.66 Pain Relevance 0.06
MDA was one of the main LPO products, its elevated levels could reflect the degrees of LPO injury in hepatocytes.[21] The increase in MDA level in isoniazid-treated rats indicates enhanced peroxidation leading to a failure of the antioxidant defense mechanism to prevent formation of excess free radicals.[22] Pretreatment with CQ prevented significantly LPO either directly or through GSH by scavenging the free radicals.
Neg (prevented) Gene_expression (prevented) of LPO in hepatocytes associated with injury
11) Confidence 0.44 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2991701 Disease Relevance 0.68 Pain Relevance 0.03
MDA was one of the main LPO products, its elevated levels could reflect the degrees of LPO injury in hepatocytes.[21] The increase in MDA level in isoniazid-treated rats indicates enhanced peroxidation leading to a failure of the antioxidant defense mechanism to prevent formation of excess free radicals.[22] Pretreatment with CQ prevented significantly LPO either directly or through GSH by scavenging the free radicals.
Gene_expression (products) of LPO in hepatocytes associated with injury
12) Confidence 0.44 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2991701 Disease Relevance 0.71 Pain Relevance 0.03
Levels of LPO in the injured sciatic nerves were significantly reduced using either early or late treatment, however tirilazad had opposing effects on recovery, prolonging or alleviating thermal hyperalgesia, respectively.
Gene_expression (Levels) of LPO in sciatic nerves associated with thermal hyperalgesia and sciatic nerve
13) Confidence 0.43 Published 2001 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11498276 Disease Relevance 0.54 Pain Relevance 0.51
Table 3 delineates the levels of LPO, 8-OHdG and protein carbonyls in the control and experimental animals.
Gene_expression (levels) of LPO
14) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2291455 Disease Relevance 0.21 Pain Relevance 0
Concomitant treatment of rats with sulphated polysaccharides significantly (P < 0.001) reduced the elevated levels of LPO, 8-OHdG and protein carbonyl close to that of controls, thereby strongly confirming its potential in inhibiting the oxidation of macromolecules like lipids, DNA and proteins.


Gene_expression (levels) of LPO
15) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2291455 Disease Relevance 0.09 Pain Relevance 0
Effect on the liver antioxidant enzymes and LPO
Gene_expression (Effect) of LPO in liver
16) Confidence 0.39 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2937313 Disease Relevance 0.72 Pain Relevance 0.03
For the assays of hepatic LPO, GSH, SOD, catalase, Se-GSHpx, and MPO, a part of the right large lobe of each liver was homogenized in 9 volumes of ice-cold 0.15 M KCl containing 1.0 mM EDTA using a glass homogenizer with a Telfon pestle.
Gene_expression (assays) of LPO in lobe associated with urological neuroanatomy
17) Confidence 0.37 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266062 Disease Relevance 0.71 Pain Relevance 0.08
Sulphated polysaccharides co-supplementation significantly prevented the oxidative damage to macromolecules, by minimizing the levels of LPO, 8-OHdG and protein carbonyls.
Gene_expression (levels) of LPO
18) Confidence 0.36 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2291455 Disease Relevance 0 Pain Relevance 0
The total protein content, lipid peroxidation (LPO), catalase and superoxide dismutase (SOD) activity were determined using standard procedures.[23]

Statistical analysis

Spec (determined) Gene_expression (determined) of LPO
19) Confidence 0.34 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2937313 Disease Relevance 1.03 Pain Relevance 0
In addition to contributing to the maintenance of the membrane integrity of hepatocytes, as inferred from the lower plasma activities of ALT, AST and LDH, serving as markers of liver damage, these compounds were also able to markedly reduce the production of MDA, an indicator of LPO, and to return the intracellular levels of GSH to values that were equal to (HYTAU) or just below (NAC, TAU) the control value.
Gene_expression (production) of LPO in hepatocytes associated with hepatotoxicity
20) Confidence 0.30 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0.17 Pain Relevance 0.22

General Comments

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