INT21722

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Context Info
Confidence 0.40
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.25
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
stomach 4
pancreas 2
Lpo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
emotional pain 1 99.26 Very High Very High Very High
Somatostatin 56 80.88 Quite High
Pain 2 75.00 Quite High
ischemia 4 54.44 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 140 99.80 Very High Very High Very High
Stress 39 99.40 Very High Very High Very High
Pain 2 99.26 Very High Very High Very High
Injury 21 89.80 High High
Apoptosis 7 63.60 Quite High
Cv Unclassified Under Development 3 54.44 Quite High
Hypoxia 27 53.92 Quite High
Acute Liver Failure 1 41.48 Quite Low
Hepatotoxicity 26 37.52 Quite Low
Coronary Artery Disease 1 18.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the diabetic rats, an increase in stomach LPO levels was observed.
Positive_regulation (increase) of Gene_expression (levels) of LPO in stomach associated with diabetes mellitus
1) Confidence 0.40 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831851 Disease Relevance 0.53 Pain Relevance 0.07
The development of emotional pain stress in rats is accompanied by an increase in lipid peroxidation (LPO) products in the pancreas and a decrease in antiradical activity of its lipids.
Positive_regulation (increase) of Gene_expression (products) of LPO in pancreas associated with stress, pain and emotional pain
2) Confidence 0.38 Published 1990 Journal Probl Endokrinol (Mosk) Section Abstract Doc Link 2194205 Disease Relevance 0.49 Pain Relevance 0.17
Administration of zinc sulfate was found to reduce stomach LPO levels in diabetic rats, but in the nondiabetic control groups, it significantly increased the stomach LPO levels (ap<0.0001).
Positive_regulation (increased) of Gene_expression (levels) of LPO in stomach associated with diabetes mellitus
3) Confidence 0.35 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831851 Disease Relevance 0.66 Pain Relevance 0.07
Concomitant treatment of rats with sulphated polysaccharides significantly (P < 0.001) reduced the elevated levels of LPO, 8-OHdG and protein carbonyl close to that of controls, thereby strongly confirming its potential in inhibiting the oxidation of macromolecules like lipids, DNA and proteins.


Positive_regulation (elevated) of Gene_expression (levels) of LPO
4) Confidence 0.32 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2291455 Disease Relevance 0.09 Pain Relevance 0
Associated with the impaired cardiac function, increases in myocardial LPO and caspase-3 were observed in H?
Positive_regulation (increases) of Gene_expression (myocardial) of LPO
5) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3006425 Disease Relevance 0.49 Pain Relevance 0.03

General Comments

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