INT217253

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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.55
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PPIG) protein folding (PPIG) nucleoplasm (PPIG)
nucleolus (PPIG) nucleus (PPIG) cytoplasm (PPIG)
PPIG (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 30 98.76 Very High Very High Very High
opiate 7 98.32 Very High Very High Very High
methadone 91 94.40 High High
Opioid 32 91.52 High High
Pain 4 60.88 Quite High
colic 1 59.80 Quite High
Buprenorphine 58 50.20 Quite High
opioid receptor 6 42.84 Quite Low
depression 2 38.36 Quite Low
agonist 5 29.60 Quite Low
Disease Link Frequency Relevance Heat
Toxicity 20 91.88 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 19 79.68 Quite High
Opiate Addiction 12 72.24 Quite High
Substance Withdrawal Syndrome 15 68.00 Quite High
Arthralgia 2 60.88 Quite High
Abdominal Cramps 1 59.80 Quite High
Anxiety Disorder 1 59.08 Quite High
Sleep Disorders 6 39.04 Quite Low
Respiratory Failure 2 38.36 Quite Low
Constipation 1 38.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, supposing that this theoretical model could be extended to CYPs (as it has been assumed in the case of CYP101 [20]), the interfacial electric field should be more intense at ?
Positive_regulation (assumed) of Positive_regulation (case) of CYP101
1) Confidence 0.08 Published 2007 Journal J Biol Inorg Chem Section Body Doc Link PMC2099460 Disease Relevance 0 Pain Relevance 0
Moreover, CYP enzyme induction requires the synthesis of new enzymes, generally over 7 to 21 days, which is therefore the time frame for onset of opiate withdrawal and need for a methadone dose increase.
Positive_regulation (requires) of Positive_regulation (induction) of CYP enzyme associated with methadone, opiate and withdrawal
2) Confidence 0.03 Published 2010 Journal Curr HIV/AIDS Rep Section Body Doc Link PMC2892618 Disease Relevance 0.55 Pain Relevance 2.33

General Comments

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