INT21726

Context Info Confidence 0.74 First Reported 1990 Last Reported 2010 Negated 3 Speculated 1 Reported most in Body Documents 10 Total Number 33 Disease Relevance 7.38 Pain Relevance 2.36

endosome (Tfrc) peptidase activity (Tfrc) mitochondrion (Tfrc) aging (Tfrc) extracellular region (Tfrc) cytoplasmic membrane-bounded vesicle (Tfrc)

Anatomy Link Frequency liver 4 hepatocytes 2 hind limb 2 tail 1 T cells 1 Tfrc (Rattus norvegicus)

Pain Link Frequency Relevance Heat depression 5 98.40 Pain 7 97.60 cytokine 336 96.32 Central nervous system 24 89.84 tricyclic antidepressant 1 89.60 Neuritis 5 89.48 fluoxetine 1 88.44 Inflammatory mediators 1 84.80 Bile 24 81.04 Inflammation 26 74.16

Disease Link Frequency Relevance Heat Syndrome 6 99.44 Targeted Disruption 49 99.42 Depression 5 98.40 Sickle Cell Anemia 16 98.12 Disease 40 97.44 Abscess 48 97.28 Chronic Renal Failure 6 94.08 Immune System Diseases 1 94.00 Anaemia 6 93.24 Experimental Autoimmune Neuritis 5 89.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Serum transferrin receptor (TfR) levels were measured in 182 children with homozygous sickle cell (SS) disease, 47 with sickle cell-haemoglobin C (SC) disease and 41 normal (AA) controls on their eighth birthday.

Gene_expression (levels) of TfR associated with sickle cell anemia and disease

1) Confidence 0.74 Published 1993 Journal Br. J. Haematol. Section Abstract Doc Link 8398834 Disease Relevance 1.08 Pain Relevance 0

Serum transferrin receptor (TfR) levels were measured in 182 children with homozygous sickle cell (SS) disease, 47 with sickle cell-haemoglobin C (SC) disease and 41 normal (AA) controls on their eighth birthday.

Gene_expression (levels) of transferrin receptor associated with sickle cell anemia and disease

2) Confidence 0.74 Published 1993 Journal Br. J. Haematol. Section Abstract Doc Link 8398834 Disease Relevance 1.08 Pain Relevance 0

Of these, the TFR in response to tail pinch was present in 16 (41%) cases.

Gene_expression (present) of TFR in tail

3) Confidence 0.60 Published 2008 Journal Surg Neurol Section Body Doc Link 18207507 Disease Relevance 0 Pain Relevance 0

However, in the 23 animals in which the TFR was absent, none showed improvement in BBB score or return of hindlimb movements.

Neg (absent) Gene_expression (absent) of TFR in hindlimb

4) Confidence 0.60 Published 2008 Journal Surg Neurol Section Body Doc Link 18207507 Disease Relevance 0 Pain Relevance 0

It is suggested that: (1) a coordinated and upregulated production of IL-6, sIL-6R, sIL-2R and TfR may constitute a trait marker of major depression; and that (2) an upregulated production of IL-6 may represent a contributing factor to the various immune disorders encountered in major depression and maybe to the pathophysiology or pathogenesis of that illness.

Gene_expression (production) of TfR associated with depression and immune system diseases

5) Confidence 0.29 Published 1995 Journal J Affect Disord Section Abstract Doc Link 8550956 Disease Relevance 0.49 Pain Relevance 0.33

Physical preconditioning significantly reduced insulin levels in both groups (TR: 0.54 ± 0.1 and TRD: 1.24 ± 0.3 ng/ml) as compared to sedentary animals (SD: 0.87 ± 0.1 and SDD: 2.57 ± 0.3 ng/ml).

Gene_expression (levels) of TR

6) Confidence 0.23 Published 2008 Journal BMC Physiol Section Abstract Doc Link PMC2443377 Disease Relevance 0.28 Pain Relevance 0

T3 treatment of hepatocytes significantly induced early gene expression of DOR, NCoR-1, and TR?

Gene_expression (expression) of TR in hepatocytes

7) Confidence 0.19 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0 Pain Relevance 0

Similar to the observations in the liver tissue during APR, a reduction in gene expression of DOR and TR?

Gene_expression (expression) of TR in liver

8) Confidence 0.16 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0 Pain Relevance 0.13

We studied hepatic gene expression of the newly identified thyroid hormone receptor (TR) cofactor DOR/TP53INP2 together with TRs in a rat model of aseptic abscesses induced by injecting intramuscular turpentine-oil into each hind limb.

Gene_expression (expression) of TR in hind limb associated with abscess

9) Confidence 0.16 Published 2010 Journal Cell Tissue Res Section Abstract Doc Link PMC2977073 Disease Relevance 0.10 Pain Relevance 0

The predominant active form of TR in a murine liver cell line is TR?

Gene_expression (form) of TR in liver

10) Confidence 0.16 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0.14 Pain Relevance 0.04

An early significant up-regulation at 1 h was also detected for the gene expression of TR?

Gene_expression (expression) of TR

11) Confidence 0.16 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0 Pain Relevance 0

2, which lacks the T3-binding domain and therefore acts as the dominant negative inhibitor of TR?

Neg (negative) Gene_expression (negative) of TR

12) Confidence 0.16 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0.12 Pain Relevance 0.04

Commensurate with the down-regulation observed for the DOR gene, similar patterns of expression have been detected for TR?

Gene_expression (detected) of TR

13) Confidence 0.16 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0 Pain Relevance 0.10

Recent experiments with knockout mice have demonstrated that absence of both TR?

Neg (absence) Gene_expression (absence) of TR associated with targeted disruption

14) Confidence 0.16 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0.24 Pain Relevance 0.04

Transcripts specific for DOR, nuclear receptor co-repressor 1 (NCoR-1), and TR?

Gene_expression (specific) of TR

15) Confidence 0.16 Published 2010 Journal Cell Tissue Res Section Abstract Doc Link PMC2977073 Disease Relevance 0.08 Pain Relevance 0.04

1 were down-regulated with a minimum at 6-12 h, whereas expression for TR?

Gene_expression (for) of TR

16) Confidence 0.16 Published 2010 Journal Cell Tissue Res Section Abstract Doc Link PMC2977073 Disease Relevance 0.07 Pain Relevance 0.04

Immunohistology revealed no significant change in the protein expression of TR?

Gene_expression (expression) of TR

17) Confidence 0.15 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0 Pain Relevance 0

Results represent means±SEM of three animals; *P<0.05 Modulation of TR gene expression in cultured rat hepatocytes

Gene_expression (expression) of TR in hepatocytes

18) Confidence 0.15 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0 Pain Relevance 0.04

This may be attributable not only to a reduced TH serum level, but also to the direct effect of acute-phase mediators on the regulation of the TR gene expression in liver cells, possibly explaining the lack of clinical effectiveness of T3 administration under acute-phase conditions.

Gene_expression (expression) of TR in liver

19) Confidence 0.15 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0.28 Pain Relevance 0

2 on TR?

Gene_expression (on) of TR

20) Confidence 0.14 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0.57 Pain Relevance 0.04

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