INT21727

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Context Info
Confidence 0.19
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.68
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tfrc) peptidase activity (Tfrc) mitochondrion (Tfrc)
aging (Tfrc) extracellular region (Tfrc) cytoplasmic membrane-bounded vesicle (Tfrc)
Anatomy Link Frequency
liver 4
hepatocytes 2
T cells 2
Tfrc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 5 98.40 Very High Very High Very High
tricyclic antidepressant 1 90.08 High High
Neuritis 5 89.88 High High
fluoxetine 1 88.92 High High
Central nervous system 4 85.60 High High
Inflammatory mediators 1 85.20 High High
Bile 4 45.52 Quite Low
cytokine 56 36.12 Quite Low
corticosteroid 4 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 6 99.64 Very High Very High Very High
Depression 5 98.40 Very High Very High Very High
Immune System Diseases 1 94.00 High High
Experimental Autoimmune Neuritis 5 89.88 High High
INFLAMMATION 5 84.80 Quite High
Targeted Disruption 8 78.96 Quite High
Nervous System Injury 1 70.56 Quite High
Injury 24 26.40 Quite Low
Diabetes Mellitus 4 25.92 Quite Low
Alzheimer's Dementia 4 10.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested that: (1) a coordinated and upregulated production of IL-6, sIL-6R, sIL-2R and TfR may constitute a trait marker of major depression; and that (2) an upregulated production of IL-6 may represent a contributing factor to the various immune disorders encountered in major depression and maybe to the pathophysiology or pathogenesis of that illness.
Positive_regulation (upregulated) of Gene_expression (production) of TfR associated with depression and immune system diseases
1) Confidence 0.19 Published 1995 Journal J Affect Disord Section Abstract Doc Link 8550956 Disease Relevance 0.49 Pain Relevance 0.33
T3 treatment of hepatocytes significantly induced early gene expression of DOR, NCoR-1, and TR?
Positive_regulation (induced) of Gene_expression (expression) of TR in hepatocytes
2) Confidence 0.17 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0 Pain Relevance 0
The predominant active form of TR in a murine liver cell line is TR?
Positive_regulation (form) of Gene_expression (form) of TR in liver
3) Confidence 0.12 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0.14 Pain Relevance 0.04
An early significant up-regulation at 1 h was also detected for the gene expression of TR?
Positive_regulation (detected) of Gene_expression (expression) of TR
4) Confidence 0.12 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0 Pain Relevance 0
The predominant active form of TR in a murine liver cell line is TR?
Positive_regulation (form) of Gene_expression (form) of TR in liver
5) Confidence 0.11 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0.14 Pain Relevance 0.04
However, circulating activated T cells can be found in patients with GBS, as evidenced by augmented expression of HLA-DR antigen, the transferrin receptor, and the interleukin-2 receptor on the surface of peripheral blood T cells, and by increased serum concentrations of interleukin-2 and the soluble interleukin-2 receptor.
Positive_regulation (augmented) of Gene_expression (expression) of transferrin receptor in T cells associated with syndrome
6) Confidence 0.02 Published 1990 Journal Ann. Neurol. Section Abstract Doc Link 2194429 Disease Relevance 0.92 Pain Relevance 0.40

General Comments

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