INT217273

Context Info Confidence 0.01 First Reported 2007 Last Reported 2007 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.09 Pain Relevance 0.04

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp) nucleus (Ptges) cytoplasm (Ptges) response to stress (Avp)

Anatomy Link Frequency microglia 2 Avp (Rattus norvegicus) Ptges (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammatory mediators 1 88.08 COX-2 inhibitor 2 24.72 ischemia 7 5.00 Inflammation 6 5.00 cytokine 1 5.00 Spinal cord 1 5.00 cva 1 5.00 Stimulus evoked pain 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 7 88.08 Brain Injury 12 5.00 Injury 4 5.00 Disease 4 5.00 Cv General 4 Under Development 3 5.00 Stress 3 5.00 Cv Unclassified Under Development 3 5.00 Brain Hemorrhage 2 5.00 Death 2 5.00 Parkinson's Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RT-PCR analysis reveals that COX-1 inhibition by SC-560 or VAS failed to reduce mPGES-1 expression in LPS-activated primary microglia (Fig. 7A and 7B).

VAS Neg (failed) Negative_regulation (reduce) of Gene_expression (expression) of mPGES-1 in microglia

1) Confidence 0.01 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0.09 Pain Relevance 0.04

General Comments

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