INT217300

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.64
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Syn1) ligase activity (Syn1)
Anatomy Link Frequency
neuronal 1
pyramidal neurons 1
Syn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 27 99.28 Very High Very High Very High
Hippocampus 17 98.44 Very High Very High Very High
Nerve growth factor 17 89.88 High High
Central nervous system 2 82.56 Quite High
anesthesia 3 50.00 Quite Low
GABAergic 2 39.60 Quite Low
Eae 7 11.64 Low Low
gABA 9 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 79 99.04 Very High Very High Very High
Infection 3 95.92 Very High Very High Very High
Tauopathy 40 84.72 Quite High
Disease 35 82.40 Quite High
Neuroblastoma 4 79.36 Quite High
Cleft Palate 11 76.40 Quite High
Alzheimer's Dementia 32 65.48 Quite High
Body Weight 19 60.00 Quite High
Frailty 3 51.52 Quite High
Shock 4 48.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In these pan-neuronal knockout mice, cre-mediated recombination was under the control of the rat synapsin I promoter.
Regulation (control) of synapsin I promoter in neuronal associated with targeted disruption
1) Confidence 0.11 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100059 Disease Relevance 0.98 Pain Relevance 0.04
For PC12 (DN-Akt) cells, cells were infected with lentivirus targeting Syn-1 (shSyn-1#2) or shControl at an MOI of 10.
Regulation (targeting) of shSyn-1
2) Confidence 0.04 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.17 Pain Relevance 0.09
Intracerebral injection of these vectors into the hippocampal complex of wild-type mice, expresses the embedded cDNA under control of the human synapsin-1 promoter, specifically in pyramidal neurons of hippocampus and cortex (Figure S1).
Regulation (control) of synapsin-1 promoter in pyramidal neurons associated with pyramidal cell and hippocampus
3) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 0.48 Pain Relevance 0.17

General Comments

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