INT217329

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Context Info
Confidence 0.19
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 11.98
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (RSAD2) endoplasmic reticulum (RSAD2) molecular_function (RSAD2)
Anatomy Link Frequency
A549 8
plaque 2
RSAD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 99 95.72 Very High Very High Very High
cytokine 45 75.04 Quite High
dexamethasone 9 27.40 Quite Low
Pain 18 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 612 99.48 Very High Very High Very High
Dengue 1134 99.36 Very High Very High Very High
Fever 144 97.16 Very High Very High Very High
Hepatitis C Virus Infection 45 96.52 Very High Very High Very High
Hepatitis 9 96.24 Very High Very High Very High
Cytomegalovirus Infection 27 95.48 Very High Very High Very High
Convalescence 18 74.96 Quite High
Disease 99 71.40 Quite High
Lower Respiratory Tract Infection 9 63.92 Quite High
Sprains And Strains 27 54.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cells were selected using 500 µg/ml G418 and screened for viperin expression by immunoblotting.
Positive_regulation (screened) of Gene_expression (expression) of viperin
1) Confidence 0.19 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 0.92 Pain Relevance 0
The use of viperin overexpressing A549 cells demonstrated that, in addition to being significantly upregulated during infection, viperin is directly involved in the anti-viral response to dengue, as shown by the suppression of dengue replication in the presence of increased expression of viperin.
Positive_regulation (increased) of Gene_expression (expression) of viperin in A549 associated with dengue and infection
2) Confidence 0.19 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.88 Pain Relevance 0
The use of viperin overexpressing A549 cells demonstrated that, in addition to being significantly upregulated during infection, viperin is directly involved in the anti-viral response to dengue, as shown by the suppression of dengue replication in the presence of increased expression of viperin.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of viperin in A549 associated with dengue and infection
3) Confidence 0.14 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.83 Pain Relevance 0
We also determined that overexpression of viperin, an upregulated gene in the IFN pathway, and proteasome inhibition, with MG-132 or ALLN, reduced virus replication.
Positive_regulation (upregulated) of Gene_expression (overexpression) of viperin
4) Confidence 0.14 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.20 Pain Relevance 0.18
We also determined that overexpression of viperin, an upregulated gene in the IFN pathway, and proteasome inhibition, with MG-132 or ALLN, reduced virus replication.
Positive_regulation (overexpression) of Gene_expression (overexpression) of viperin
5) Confidence 0.14 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.19 Pain Relevance 0.18
had the greater anti-viral effect, viperin over expression alone resulted in a small, but significant, reduction in virus production both with (P?
Positive_regulation (resulted) of Gene_expression (expression) of viperin
6) Confidence 0.14 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.17 Pain Relevance 0
In order to investigate the role of viperin in dengue infection, we used an established A549 cell line stably overexpressing viperin (Vip) [26].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of viperin in A549 associated with dengue and infection
7) Confidence 0.14 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.33 Pain Relevance 0
Comparing to infection in wild type A549 cells (WT), viperin overexpressing cells were significantly resistant to viral replication, as shown by plaque assay two days after infection (Figure 5A), with and without pre-treatment with IFN?
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of viperin in plaque associated with infection
8) Confidence 0.14 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.30 Pain Relevance 0
A highly upregulated gene in the IFN pathway, viperin, was overexpressed in A549 cells resulting in a significant reduction in viral replication.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of viperin in A549
9) Confidence 0.14 Published 2007 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2100376 Disease Relevance 1.16 Pain Relevance 0.05

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