INT217330

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.67
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SUMO1) nucleus (SUMO1) cytoplasm (SUMO1)
SUMO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 11 98.36 Very High Very High Very High
metalloproteinase 14 50.00 Quite Low
agonist 1 50.00 Quite Low
Inflammation 10 22.48 Low Low
chemokine 11 5.00 Very Low Very Low Very Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
Osteoarthritis 5 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dengue 126 99.20 Very High Very High Very High
Hepatitis C Virus Infection 5 98.98 Very High Very High Very High
Infection 68 93.24 High High
Hepatitis 1 59.56 Quite High
Cytomegalovirus Infection 3 58.80 Quite High
Disease 13 34.72 Quite Low
Influenza Virus Infection 2 26.80 Quite Low
Equine Infectious Anemia 1 25.28 Quite Low
INFLAMMATION 11 22.48 Low Low
Chondrosarcoma 6 12.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that treatment with a proinflammatory cytokine may activate pathways that cause removal of SUMO1 from conjugated RXR or perhaps degradation of doubly SUMO1-ylated RXR (see Discussion).
Protein_catabolism (degradation) of SUMO1 associated with cytokine
1) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0.09
HCV polymerase has also been shown to interact with a ubiquitin-like protein leading to its degradation [43].
Protein_catabolism (degradation) of ubiquitin-like protein associated with hepatitis c virus infection
2) Confidence 0.13 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.67 Pain Relevance 0

General Comments

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