INT217333

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.65
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNFAIP3) peptidase activity (TNFAIP3) nucleus (TNFAIP3)
DNA binding (TNFAIP3) ligase activity (TNFAIP3) cytoplasm (TNFAIP3)
Anatomy Link Frequency
A20 1
inferior 1
TNFAIP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 11 26.96 Quite Low
cytokine 9 12.08 Low Low
Inflammation 7 11.68 Low Low
Pain 7 5.00 Very Low Very Low Very Low
Anterior cingulate cortex 5 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
drug abuse 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
amygdala 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 274 99.32 Very High Very High Very High
Infection 120 96.76 Very High Very High Very High
Necrosis 6 88.00 High High
Cancer 16 87.64 High High
Dengue 126 80.96 Quite High
Targeted Disruption 4 63.36 Quite High
Convalescence 2 61.40 Quite High
Fever 16 60.68 Quite High
Shigella Infection 6 31.40 Quite Low
Dna Damage 2 12.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upregulation of TNFAIP3, TNFAIP8, TNFRSF12A, FAIM3, and CFLAR are important to inhibit caspase-8 activation, and may be direct targets of Shigella T3SS effector proteins or result from NF-?
Positive_regulation (Upregulation) of TNFAIP3
1) Confidence 0.23 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 1.03 Pain Relevance 0
Interestingly, TNFAIP3, also known as A20, was also induced in a previous microarray analysis of Shigella-infected cells [4].
Positive_regulation (induced) of TNFAIP3 in A20
2) Confidence 0.16 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 1.15 Pain Relevance 0
For example, the upregulation of IP-10, I-TAC, VEGF, PAI1, B2M, TNFAIP3 and RIG-1 could all be linked to the activation of NF-?
Positive_regulation (upregulation) of TNFAIP3
3) Confidence 0.14 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 0.47 Pain Relevance 0
Furthermore, both women and men exhibited activation of the right inferior temporal gyrus (ITG, BA20).
Positive_regulation (activation) of BA20 in inferior
4) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2453130 Disease Relevance 0 Pain Relevance 0

General Comments

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