INT217344

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Context Info
Confidence 0.22
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 17.78
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (RSAD2) endoplasmic reticulum (RSAD2) molecular_function (RSAD2)
Anatomy Link Frequency
A549 7
plaque 1
RSAD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 141 95.72 Very High Very High Very High
cytokine 96 75.04 Quite High
Inflammation 84 40.40 Quite Low
dexamethasone 12 27.40 Quite Low
Pain 24 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
Angina 9 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dengue 1512 99.84 Very High Very High Very High
Cytomegalovirus Infection 57 99.68 Very High Very High Very High
Infection 855 99.48 Very High Very High Very High
Atherosclerosis 201 98.24 Very High Very High Very High
Fever 192 97.16 Very High Very High Very High
Hepatitis C Virus Infection 60 96.52 Very High Very High Very High
Hepatitis 12 96.24 Very High Very High Very High
Stress 6 90.52 High High
Apoptosis 42 83.76 Quite High
Convalescence 24 83.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Generation of A549 cells stably expressing viperin and treatment with IFN?
Gene_expression (expressing) of viperin in A549
1) Confidence 0.22 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 0.86 Pain Relevance 0
Cells were selected using 500 µg/ml G418 and screened for viperin expression by immunoblotting.
Gene_expression (expression) of viperin
2) Confidence 0.22 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 0.92 Pain Relevance 0
A highly upregulated gene in the IFN pathway, viperin, was overexpressed in A549 cells resulting in a significant reduction in viral replication.
Gene_expression (overexpressed) of viperin in A549
3) Confidence 0.22 Published 2007 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2100376 Disease Relevance 1.16 Pain Relevance 0.05
The use of viperin overexpressing A549 cells demonstrated that, in addition to being significantly upregulated during infection, viperin is directly involved in the anti-viral response to dengue, as shown by the suppression of dengue replication in the presence of increased expression of viperin.
Gene_expression (expression) of viperin in A549 associated with dengue and infection
4) Confidence 0.22 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.82 Pain Relevance 0
We also determined that overexpression of viperin, an upregulated gene in the IFN pathway, and proteasome inhibition, with MG-132 or ALLN, reduced virus replication.
Gene_expression (overexpression) of viperin
5) Confidence 0.22 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.19 Pain Relevance 0.18
The use of viperin overexpressing A549 cells demonstrated that, in addition to being significantly upregulated during infection, viperin is directly involved in the anti-viral response to dengue, as shown by the suppression of dengue replication in the presence of increased expression of viperin.
Gene_expression (overexpressing) of viperin in A549 associated with dengue and infection
6) Confidence 0.22 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.83 Pain Relevance 0
In order to investigate the role of viperin in dengue infection, we used an established A549 cell line stably overexpressing viperin (Vip) [26].
Gene_expression (overexpressing) of viperin in A549 associated with dengue and infection
7) Confidence 0.22 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.33 Pain Relevance 0
had the greater anti-viral effect, viperin over expression alone resulted in a small, but significant, reduction in virus production both with (P?
Gene_expression (expression) of viperin
8) Confidence 0.22 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.17 Pain Relevance 0
Comparing to infection in wild type A549 cells (WT), viperin overexpressing cells were significantly resistant to viral replication, as shown by plaque assay two days after infection (Figure 5A), with and without pre-treatment with IFN?
Gene_expression (overexpressing) of viperin in plaque associated with infection
9) Confidence 0.22 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.30 Pain Relevance 0
These results suggest that viperin is an functional component of the IFN-mediated response to dengue, and demonstrate, for the first time, that viperin could be part of the anti-dengue response.


Gene_expression (response) of viperin associated with dengue
10) Confidence 0.19 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.04 Pain Relevance 0
A highly upregulated gene in the IFN pathway, viperin, was overexpressed in A549 cells resulting in a significant reduction in viral replication.
Gene_expression (overexpressed) of viperin in A549
11) Confidence 0.19 Published 2007 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2100376 Disease Relevance 1.16 Pain Relevance 0.05
A549 cells were transfected with an expression construct encoding viperin using lipofectamine 2000 (Invitrogen, USA).
Gene_expression (expression) of viperin in A549
12) Confidence 0.16 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 0.96 Pain Relevance 0
the expression of the viperin gene.
Gene_expression (expression) of viperin
13) Confidence 0.11 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 1.02 Pain Relevance 0
Viperin, which is highly
Gene_expression (is) of Viperin
14) Confidence 0.09 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 1.01 Pain Relevance 0
The human viperin gene has been suggested
Gene_expression (gene) of viperin
15) Confidence 0.09 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 1.01 Pain Relevance 0

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