INT21737

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Context Info
Confidence 0.48
First Reported 1990
Last Reported 2011
Negated 3
Speculated 6
Reported most in Abstract
Documents 129
Total Number 135
Disease Relevance 45.45
Pain Relevance 56.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (MC1R) plasma membrane (MC1R) signal transducer activity (MC1R)
Anatomy Link Frequency
skin 22
melanocytes 13
pigmentation 12
hair 9
basal cell 2
MC1R (Homo sapiens)
MC1R - D84E (2)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 3604 100.00 Very High Very High Very High
agonist 61 100.00 Very High Very High Very High
opiate 6 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
Pain 146 99.56 Very High Very High Very High
Inflammation 36 99.48 Very High Very High Very High
antagonist 26 99.42 Very High Very High Very High
Opioid 10 98.64 Very High Very High Very High
analgesia 7 98.36 Very High Very High Very High
Central nervous system 15 94.68 High High
Disease Link Frequency Relevance Heat
Skin Cancer 509 100.00 Very High Very High Very High
Hypopigmentation 11 100.00 Very High Very High Very High
Melanoma 2940 99.98 Very High Very High Very High
Disease 109 99.98 Very High Very High Very High
Cancer 250 99.92 Very High Very High Very High
Freckles 99 99.76 Very High Very High Very High
Basal Cell Carcinoma 9 99.76 Very High Very High Very High
Pain 152 99.56 Very High Very High Very High
INFLAMMATION 39 99.48 Very High Very High Very High
Obesity 110 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A causal association between red hair and melanocortin-1 receptor has been shown, and is the only gene that is known to explain physiological variation in human pigmentation.
melanocortin-1 receptor Binding (association) of in hair associated with melanocortin 1 receptor
1) Confidence 0.48 Published 2009 Journal Med. Hypotheses Section Abstract Doc Link 19482440 Disease Relevance 1.02 Pain Relevance 0.22
We also observed a multiplicative interaction of risk due to the MC1R variants and the common allele (high risk) of the T241M polymorphism in the XRCC3 gene.
MC1R Binding (interaction) of associated with melanocortin 1 receptor
2) Confidence 0.48 Published 2008 Journal Int. J. Cancer Section Abstract Doc Link 18067130 Disease Relevance 0.29 Pain Relevance 0.70
Sequence variation of the MC1R gene (MC1R) has been associated with pigmentation phenotypes in humans and in several animal species.
MC1R Binding (associated) of in pigmentation associated with melanocortin 1 receptor
3) Confidence 0.48 Published 2008 Journal Am. J. Primatol. Section Abstract Doc Link 18454455 Disease Relevance 0 Pain Relevance 0.54
Sequence variation of the MC1R gene (MC1R) has been associated with pigmentation phenotypes in humans and in several animal species.
MC1R Binding (associated) of in pigmentation associated with melanocortin 1 receptor
4) Confidence 0.48 Published 2008 Journal Am. J. Primatol. Section Abstract Doc Link 18454455 Disease Relevance 0 Pain Relevance 0.54
Interaction between the melanocortin-1 receptor and P genes contributes to inter-individual variation in skin pigmentation phenotypes in a Tibetan population.
melanocortin-1 receptor Binding (Interaction) of in skin associated with melanocortin 1 receptor
5) Confidence 0.48 Published 2001 Journal Hum. Genet. Section Title Doc Link 11499678 Disease Relevance 0.09 Pain Relevance 0.37
Any information on the occurrence of single or multiple primary melanoma was not available for this analysis; however, we plan to investigate in the near future whether the association of MC1R with age at melanoma diagnosis differs in single vs multiple primary melanoma.
MC1R Spec (whether) Binding (association) of associated with melanocortin 1 receptor and melanoma
6) Confidence 0.48 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 0.90 Pain Relevance 0.37
Case–control studies have indicated that part of the association between melanoma risk and MC1R variants remains after stratification of phenotypic features suggesting that the association of MC1R is not exerted entirely through pigmentation (21,46–48).
MC1R Binding (association) of in pigmentation associated with melanocortin 1 receptor and melanoma
7) Confidence 0.48 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 0.54 Pain Relevance 0.78
The swans (Cygnus) provide a simple system of colour variation for investigating whether MC1R has a role in interspecific colour differences, and are in the same family as the lesser snow goose which shows intraspecific association between MC1R genotype and plumage melanism.
MC1R Binding (association) of associated with freckles
8) Confidence 0.48 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2553801 Disease Relevance 0.10 Pain Relevance 0
These effects are mediated by binding of these hormones to the specific MC1R that recognizes them both with similar affinity.
MC1R Binding (binding) of associated with melanocortin 1 receptor
9) Confidence 0.48 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10816645 Disease Relevance 0 Pain Relevance 0.58
These effects are mediated by binding of these hormones to the specific MC1R that recognizes them both with similar affinity.
MC1R Binding (recognizes) of associated with melanocortin 1 receptor
10) Confidence 0.48 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10816645 Disease Relevance 0 Pain Relevance 0.58
This study has confirmed these pigmentary associations with MC1R genotype in a collection of 220 individuals drawn from the Nambour community in Queensland, Australia, 111 of whom were at high risk and 109 at low risk of basal cell carcinoma and squamous cell carcinoma.
MC1R Binding (associations) of in basal cell associated with skin cancer
11) Confidence 0.48 Published 2001 Journal J. Invest. Dermatol. Section Abstract Doc Link 11179997 Disease Relevance 0.55 Pain Relevance 0.07
After adjusting for the effects of pigmentation on the association between MC1R variant alleles and basal cell carcinoma and squamous cell carcinoma risk, the association persisted, confirming that presence of at least one variant allele remains informative in terms of predicting risk for developing a solar-induced skin lesion beyond that information wained through observation of pigmentation phenotype.
MC1R Binding (association) of in basal cell associated with skin cancer
12) Confidence 0.48 Published 2001 Journal J. Invest. Dermatol. Section Abstract Doc Link 11179997 Disease Relevance 0.79 Pain Relevance 0.07
The objective of this study was to assess the association between melanocortin-1 receptor (MC1R) variants and the severity of facial skin photoaging.
MC1R Binding (association) of in skin associated with melanocortin 1 receptor and wrinkles
13) Confidence 0.47 Published 2010 Journal J. Invest. Dermatol. Section Abstract Doc Link 19924138 Disease Relevance 0.40 Pain Relevance 0.34
Furthermore, no associations between MC1R genotype and pigment phenotype were found.
MC1R Neg (no) Binding (associations) of
14) Confidence 0.47 Published 2001 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 11481256 Disease Relevance 0.08 Pain Relevance 0
This release was significantly increased in the presence of melanotropin-related peptides such as corticotropin-(4-10)-peptide and beta-melanotropin, competing for binding to the melanotropin receptor and was directly correlated to the displacement potential of these peptides.
melanotropin receptor Binding (binding) of
15) Confidence 0.47 Published 1997 Journal Eur. J. Biochem. Section Abstract Doc Link 9108267 Disease Relevance 0.84 Pain Relevance 0.06
In addition, electrophoretic mobility shift assay indicated that nuclear extracts of human SK-Mel-2 cells contain a protein that binds specifically to the MC1R promoter region containing the CATGTG motif.
MC1R Binding (binds) of associated with melanocortin 1 receptor
16) Confidence 0.47 Published 2002 Journal Life Sci. Section Abstract Doc Link 12204775 Disease Relevance 0.15 Pain Relevance 0.70
The binding of agouti to MC1R activates the signal transduction events that lead to pheomelanin synthesis (Akey et al. 2001; Rees, 2003).
MC1R Binding (binding) of associated with melanocortin 1 receptor
17) Confidence 0.46 Published 2007 Journal Evolutionary Bioinformatics Online Section Body Doc Link PMC2684124 Disease Relevance 0.13 Pain Relevance 0.37
Interactions between MC1R genotypes and skin colour influenced DLBCL risk; the RR genotype increased risk in individuals with medium or dark skin, based on 5 cases and no controls, but decreased risk among those of fair skin.
MC1R Binding (Interactions) of in skin associated with melanocortin 1 receptor and diffuse large b-cell lymphoma
18) Confidence 0.45 Published 2010 Journal Cancer Epidemiol Section Abstract Doc Link 20129839 Disease Relevance 0.99 Pain Relevance 0.65
Our study is the first report to show a clear association of MC1R variants on melanogenic phenotypes in Asians and also indicates the importance of Arg163Gln.
MC1R Spec (clear) Binding (association) of associated with melanocortin 1 receptor
19) Confidence 0.45 Published 2007 Journal Pigment Cell Res. Section Abstract Doc Link 17371441 Disease Relevance 0.41 Pain Relevance 0.39
In mouse follicular melanocytes, the switch between eumelanin and pheomelanin synthesis is regulated by the extension locus, which encodes the melanocortin-1 receptor (MC1R) and the agouti locus, which encodes a novel paracrine-signaling molecule that inhibits binding of melanocortins to the MC1R.
MC1R Binding (binding) of in melanocytes associated with melanocortin 1 receptor
20) Confidence 0.44 Published 1997 Journal J. Invest. Dermatol. Section Abstract Doc Link 9182807 Disease Relevance 0 Pain Relevance 0.47

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