INT217370

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Context Info
Confidence 0.63
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.80
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
neuron 1
Apoe (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 63 98.48 Very High Very High Very High
Inflammatory response 14 95.36 Very High Very High Very High
Limbic system 4 88.12 High High
Thalamus 8 76.52 Quite High
chemokine 3 60.72 Quite High
Hippocampus 24 57.56 Quite High
cytokine 12 47.28 Quite Low
Inflammatory mediators 2 13.52 Low Low
cINOD 37 5.00 Very Low Very Low Very Low
long-term potentiation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 189 99.96 Very High Very High Very High
INFLAMMATION 81 98.48 Very High Very High Very High
Disease 97 95.44 Very High Very High Very High
Alzheimer's Dementia 169 82.60 Quite High
Amyloid Plaque 49 73.44 Quite High
Vascular Disease 16 65.80 Quite High
Brain Disease 4 60.72 Quite High
Neurological Disease 2 53.92 Quite High
Aging 3 52.32 Quite High
Death 19 43.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In various transgenic lines in which human ApoE3 or ApoE4 was expressed under a GFAP or a neuron-specific enolase (NSE) promoter, C-terminal fragments of ApoE4 (and to a lesser degree of ApoE3) accumulated, and tau protein appeared to be hyperphosphorylated only in the NSE-ApoE Tg mice [34].


Phosphorylation (hyperphosphorylated) of ApoE in neuron associated with targeted disruption
1) Confidence 0.63 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.41 Pain Relevance 0.13
, phosphorylated tau, ApoE and ?
Phosphorylation (phosphorylated) of ApoE
2) Confidence 0.33 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.39 Pain Relevance 0.36

General Comments

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