INT217377

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Context Info
Confidence 0.71
First Reported 2004
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.28
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dysf)
Anatomy Link Frequency
plasma 1
cardiac myocytes 1
Dysf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 22 19.24 Low Low
long-term potentiation 8 17.16 Low Low
Limbic system 3 13.92 Low Low
Hippocampus 26 5.00 Very Low Very Low Very Low
agonist 12 5.00 Very Low Very Low Very Low
Thalamus 8 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Opioid 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 171 97.48 Very High Very High Very High
Sprains And Strains 426 85.00 Quite High
Frailty 19 75.32 Quite High
Muscle Disease 6 74.24 Quite High
Distal Myopathy 2 71.12 Quite High
Myocardial Infarction 2 70.24 Quite High
Alzheimer's Dementia 160 63.72 Quite High
Hypertrophy 6 62.48 Quite High
Cognitive Disorder 27 61.04 Quite High
Disease 32 57.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dysferlin is expressed predominantly in the skeletal muscle and localizes to the plasma membrane of the muscle fibers.
Gene_expression (expressed) of Dysferlin in plasma
1) Confidence 0.71 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816849 Disease Relevance 0.34 Pain Relevance 0
For the 28 cases of elements computationally detected in A/J (cases 1–28 in Table 1), the ETn insertion in the dysferlin (Dysf ) gene (case #9) is the only previously reported case and occurred 20–30 years ago in the A/J breeding stocks [38].
Gene_expression (insertion) of dysferlin
2) Confidence 0.65 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2265474 Disease Relevance 0.50 Pain Relevance 0
The sense-oriented ETn element found in the Dysf gene in A/J has already been shown to cause similar splicing defects [38] and we did not examine A2bp1.
Gene_expression (found) of Dysf
3) Confidence 0.63 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2265474 Disease Relevance 0 Pain Relevance 0
For the 28 cases of elements computationally detected in A/J (cases 1–28 in Table 1), the ETn insertion in the dysferlin (Dysf ) gene (case #9) is the only previously reported case and occurred 20–30 years ago in the A/J breeding stocks [38].
Gene_expression (insertion) of Dysf
4) Confidence 0.63 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2265474 Disease Relevance 0.50 Pain Relevance 0
In all the cases with dysferlin deficiency, the immunocytochemical study showed normal reactivity against dystrophin, ?
Gene_expression (deficiency) of dysferlin
5) Confidence 0.62 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816849 Disease Relevance 0.06 Pain Relevance 0
Seven such cases exist, involving ETns in the Dnajc10, Dysf, Opcml, Prkca, A2bp1, Mtm1, and Col4a6 genes.
Gene_expression (involving) of Dysf
6) Confidence 0.24 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2265474 Disease Relevance 0 Pain Relevance 0
PAN-selective antibodies against PDE4A (AC55), PDE4B (K118), and PDE4D (M3S1), as well as splice variant-selective antibodies against PDE4D3, 4, 5, 8, and 9 (Richter et al, 2005), were used in IPs to determine the expression of the respective PDE4 subtype and splice variant in cardiac myocytes (Figure 2), as well as their PKA-dependent activation after ?
Spec (determine) Gene_expression (expression) of variant in cardiac myocytes
7) Confidence 0.01 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0.24 Pain Relevance 0
To analyze the mechanism of progression of the NFT, mice expressing a repressible human tau variant (rTg4510) were generated.
Gene_expression (expressing) of variant
8) Confidence 0.01 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.64 Pain Relevance 0

General Comments

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