INT217382

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2010
Negated 1
Speculated 6
Reported most in Body
Documents 26
Total Number 32
Disease Relevance 17.00
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Anatomy Link Frequency
brain 12
neurons 2
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 397 99.84 Very High Very High Very High
cytokine 112 99.78 Very High Very High Very High
Hippocampus 174 97.80 Very High Very High Very High
glial activation 28 97.20 Very High Very High Very High
agonist 46 92.36 High High
cINOD 262 90.64 High High
ischemia 111 89.12 High High
long-term potentiation 18 79.92 Quite High
imagery 33 66.20 Quite High
positron emission tomography 19 65.88 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 734 100.00 Very High Very High Very High
INFLAMMATION 488 99.84 Very High Very High Very High
Neurodegenerative Disease 53 99.76 Very High Very High Very High
Stress 676 99.28 Very High Very High Very High
Cognitive Disorder 416 99.00 Very High Very High Very High
Disease 2341 98.96 Very High Very High Very High
Hypoxia 302 98.52 Very High Very High Very High
Targeted Disruption 1004 97.80 Very High Very High Very High
Amyloid Plaque 282 95.84 Very High Very High Very High
Brain Injury 152 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors reported that BACE1 expression is regulated by age-dependent post-transcriptional regulatory mechanism in Tg2576 mice.
Regulation (regulated) of Gene_expression (expression) of BACE1
1) Confidence 0.61 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.38 Pain Relevance 0
In order to gain insight into the regulation of BACE1 gene expression, both the human and rodent BACE1 gene promoters have been sequenced and analyzed [176-179].
Regulation (regulation) of Gene_expression (expression) of BACE1 gene
2) Confidence 0.61 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.09 Pain Relevance 0
Understanding the regulation of BACE1 expression may illuminate the role of BACE1 in normal biology, identify mechanisms that lead to disease, and might suggest approaches to inhibit BACE1 therapeutically.
Regulation (regulation) of Gene_expression (expression) of BACE1 associated with disease
3) Confidence 0.61 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.08 Pain Relevance 0.07
It is clear that BACE1 expression is regulated in a complex manner, both at the transcriptional and post-transcriptional level.
Regulation (regulated) of Gene_expression (expression) of BACE1
4) Confidence 0.61 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.66 Pain Relevance 0.06
Here the regulation of BACE1 expression is discussed in detail.
Regulation (regulation) of Gene_expression (expression) of BACE1
5) Confidence 0.61 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.84 Pain Relevance 0.06
The activation of specific intracellular signaling molecules appears to be involved in the regulation of BACE1 expression in the brain.
Regulation (regulation) of Gene_expression (expression) of BACE1 in brain
6) Confidence 0.61 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.34 Pain Relevance 0
Furthermore, proinflammatory cytokines appear to modulate BACE1 expression [91,92] and following A?
Spec (appear) Regulation (modulate) of Gene_expression (expression) of BACE1 associated with cytokine
7) Confidence 0.61 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.38 Pain Relevance 0.05
As detailed previously, BACE1 expression is regulated by multiple mechanisms in a complex manner [73,83,84,225].
Regulation (regulated) of Gene_expression (expression) of BACE1
8) Confidence 0.61 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.77 Pain Relevance 0
While it is apparent that BACE1 expression can be tightly regulated at the transcriptional level, in some studies BACE1 mRNA levels in either neurons or astrocytes around amyloid plaques in APP transgenic brain are not elevated [97,100,101], implying that a post-translational mechanism may be responsible for the BACE1 increase.
Regulation (regulated) of Gene_expression (expression) of BACE1 in neurons associated with targeted disruption and amyloid plaque
9) Confidence 0.61 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.32 Pain Relevance 0.19
In parallel with changes in BACE1 expression, 5-day restraint stress significantly increased phospho-eIF2?
Regulation (changes) of Gene_expression (expression) of BACE1 associated with stress
10) Confidence 0.54 Published 2010 Journal Mol Brain Section Body Doc Link PMC2988063 Disease Relevance 0.63 Pain Relevance 0.11
Evidence has been presented for regulation of BACE1 expression at the translational level.
Regulation (regulation) of Gene_expression (expression) of BACE1
11) Confidence 0.53 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.64 Pain Relevance 0.23
Given that Tg2576 mice overexpress human APP with the Swedish mutation, Zohar and colleagues speculated that it was this APP overexpression in Tg2576 mice that effected the differential expression of BACE1 splice variants in these animals and suggested that APP may exert a regulatory role on BACE1 transcripts.
Regulation (effected) of Gene_expression (expression) of BACE1
12) Confidence 0.53 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.37 Pain Relevance 0
may account for the preserved elevation of BACE1, which corresponds to wild-type levels (i.e., twice the gene copy number), in the older BACE1+/?
Spec (may) Regulation (account) of Gene_expression (elevation) of BACE1
13) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.06 Pain Relevance 0
While total BACE1 mRNA levels did not change in Tg2576 mice, the expression profiles of the BACE1 splice variants not only differed between Tg and non-Tg mice, but also changed with age.
Neg (not) Regulation (change) of Gene_expression (levels) of BACE1 mRNA associated with targeted disruption
14) Confidence 0.45 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.40 Pain Relevance 0
burden appears sensitive to BACE1 dosage in young animals, with A?
Spec (appears) Regulation (sensitive) of Gene_expression (dosage) of BACE1
15) Confidence 0.45 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.44 Pain Relevance 0
burden appears sensitive to BACE1 dosage in young animals, with A?
Spec (appears) Regulation (sensitive) of Gene_expression (dosage) of BACE1
16) Confidence 0.45 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.47 Pain Relevance 0.06
We recently conducted studies to determine whether BACE1 deficiency, and the consequent ablation of A?
Spec (determine) Regulation (determine) of Gene_expression (deficiency) of BACE1
17) Confidence 0.45 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.69 Pain Relevance 0.04
levels in relation to the changes in BACE1 levels observed in BACE1+/?
Regulation (changes) of Gene_expression (levels) of BACE1
18) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.22 Pain Relevance 0
Therefore, it is interesting to argue that genetic reductions of BACE1, and consequently of A?
Regulation (consequently) of Gene_expression (reductions) of BACE1
19) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.22 Pain Relevance 0.04
deletion in 5XFAD mice with age, we compared changes in BACE1 levels in these mouse brain samples (Fig. 4).
Regulation (changes) of Gene_expression (levels) of BACE1 in brain
20) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.06 Pain Relevance 0

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