INT217385

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.46
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Anatomy Link Frequency
other parts 2
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 1 38.20 Quite Low
Inflammation 31 5.00 Very Low Very Low Very Low
Hippocampus 20 5.00 Very Low Very Low Very Low
Thalamus 9 5.00 Very Low Very Low Very Low
long-term potentiation 8 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Peripheral nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 202 93.08 High High
Neurodegenerative Disease 11 91.40 High High
Alzheimer's Dementia 182 90.04 High High
Convulsion 1 76.80 Quite High
Vascular Disease 16 54.80 Quite High
Amyloid Plaque 48 28.64 Quite Low
Disease 169 5.00 Very Low Very Low Very Low
Cognitive Disorder 40 5.00 Very Low Very Low Very Low
INFLAMMATION 34 5.00 Very Low Very Low Very Low
Stress 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whether dephosphorylation regulates BACE1 trafficking in other parts of the trafficking cycle remains to be determined.
Spec (Whether) Regulation (regulates) of BACE1 Binding (trafficking) of in other parts
1) Confidence 0.39 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0 Pain Relevance 0
The effect was even spectacular in PDAPP mice heterozygous for BACE1, although the decrease in A?
Regulation (effect) of BACE1 Binding (heterozygous) of
2) Confidence 0.25 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.46 Pain Relevance 0

General Comments

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