INT217386

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.67
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car1) Golgi apparatus (Car1) cytoplasm (Car1)
Anatomy Link Frequency
dentate gyrus 2
Car1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 24 97.88 Very High Very High Very High
depression 8 92.96 High High
antagonist 6 89.36 High High
Neurotransmitter 2 63.04 Quite High
Spinal cord 4 43.72 Quite Low
imagery 2 33.72 Quite Low
Neuronal excitability 17 19.84 Low Low
Inflammation 20 5.00 Very Low Very Low Very Low
long-term potentiation 8 5.00 Very Low Very Low Very Low
Thalamus 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 3 97.24 Very High Very High Very High
Anaerobic Bacterial Infections 8 95.04 Very High Very High Very High
Depression 8 92.96 High High
Targeted Disruption 248 89.72 High High
Generaliased Trisomy 3 71.32 Quite High
Down Syndrome 8 70.72 Quite High
Alzheimer's Dementia 160 66.72 Quite High
Increased Venous Pressure Under Development 2 30.12 Quite Low
Convulsion 69 17.20 Low Low
Amyloid Plaque 38 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conditional loss of Cdk5 leads to an enhancement in CA1 hippocampal post-tetanic potentiation
Negative_regulation (loss) of Positive_regulation (enhancement) of CA1
1) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.79 Pain Relevance 0.17
A reorganization of cholinergic innervation (reduction of acetylcholinesterase-positive fibers in the subiculum; increased fiber density in CA1 and in the dentate gyrus) has also been mentioned [38].
Negative_regulation (reduction) of Positive_regulation (increased) of CA1 in dentate gyrus
2) Confidence 0.11 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.87 Pain Relevance 0.08

General Comments

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