INT217387

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.01
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abca1) Golgi apparatus (Abca1) ATPase activity (Abca1)
plasma membrane (Abca1) intracellular (Abca1)
Anatomy Link Frequency
liver 1
Abca1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 1 92.40 High High
agonist 41 77.68 Quite High
Thalamus 8 70.88 Quite High
Inflammation 34 53.60 Quite High
Bile 5 26.72 Quite Low
cINOD 8 22.80 Low Low
COX-2 inhibitor 2 13.52 Low Low
Hippocampus 18 5.00 Very Low Very Low Very Low
long-term potentiation 8 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colorectal Cancer 36 99.84 Very High Very High Very High
Disorder Of Lipid Metabolism 304 95.88 Very High Very High Very High
Alzheimer's Dementia 160 90.32 High High
Targeted Disruption 175 88.64 High High
Colon Cancer 1 86.64 High High
Apoptosis 7 74.52 Quite High
Death 26 74.00 Quite High
Atherosclerosis 56 68.24 Quite High
Vascular Disease 16 67.28 Quite High
INFLAMMATION 36 53.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
deposition by other proteins involved in cholesterol metabolism: liver X receptor, LRP and ABCA1
Regulation (deposition) of ABCA1 in liver
1) Confidence 0.27 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.50 Pain Relevance 0.06
Interestingly, indomethacin down-regulates the expression of some of the ABC transporters, which are up regulated in CRC [38,41].
Regulation (regulated) of ABC associated with colorectal cancer
2) Confidence 0.26 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 0.74 Pain Relevance 0.09
The ABCA-1 receptor molecule is responsible for lipidating only newly secreted apoA-1, while the ABCG-1 and SR-B1 receptors can directly lipidate HDL molecule.
Regulation (responsible) of ABCA-1 receptor associated with disorder of lipid metabolism
3) Confidence 0.10 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.78 Pain Relevance 0

General Comments

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